The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats

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dc.authoridKöylü, Ayşe/0000-0001-8344-814X
dc.authoridDİZAKAR, Saadet Özen AKARCA/0000-0002-4358-6510
dc.authoridsipahi, mehmet/0000-0001-8344-9863
dc.authorwosidKöylü, Ayşe/AAY-5070-2021
dc.authorwosidKöylü, Ayşe/ACR-1233-2022
dc.authorwosidDİZAKAR, Saadet Özen AKARCA/AAA-1367-2021
dc.contributor.authorAkarca-Dizakar,Saadet Özen
dc.contributor.authorDemirel, Mürşide Ayşe
dc.contributor.authorCoşkun Akçay, Neslihan
dc.contributor.authorSipahi, Mehmet
dc.contributor.authorKarakoç Sökmensüer, Lale
dc.contributor.authorBoyunağa, Hakan
dc.contributor.authorKöylü, Ayşe
dc.date.accessioned2023-03-22T19:47:40Z
dc.date.available2023-03-22T19:47:40Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractThe aim of this study was to evaluate the effects of coenzyme Q10 in the treatment of endometriosis rat models. Twenty seven Sprague Dawley rats were divided into four groups; Control Group (n = 7; Endometriosis group), Reference Group (n = 6; Endometriosis + Buserelin acetate, 20 mg/kg), CoQ10 Group-I (n = 7; Endometriosis + CoQ10, 50 mg/kg) and CoQ10 Group-II (n = 7; Endometriosis + CoQ10, 100 mg/kg). At the end of the experiment, all the rats were sacrificed, and the volume and histoarchitecture of endometrial implants were evaluated. The mast cells were determined by Toluidine blue and collagen fiber density was analysed by Masson's Trichrome staining. Tumour necrosis factor and vascular endothelial growth factor (VEGF) levels were analysed by enzyme-linked immunosorbent assay in peritoneal fluid and VEGF and matrix metalloproteinase-9 (MMP-9) were evaluated by immunohistochemistry. Terminal deoxynucleotidil transferase-mediated dUTP Nick end labelling (TUNEL) was also used for the detection of apoptotic cells. The CoQ10 treatment significantly decreased the volume of endometriotic implants, VEGF, and MMP-9 immunoreactivity and increased TUNEL-positive cells. The findings of the study suggest that CoQ10 can be used in endometriosis treatment by suppressing the endometriotic implants.IMPACT STATEMENT What is already known on this subject? Endometriosis is a gynaecological disorder and previous studies have shown that different treatments with antioxidants cause significant regression in the endometriotic implants. What the results of this study add? In this study, CoQ10 reduced intra-abdominal adhesion scores and volume of the endometriotic implants. In addition, CoQ10 treatment affected mast cell, TNF-alpha, VEGF, and MMP-9. What of these findings for clinical practice and/or further research? CoQ10 treatments may be possible to apply, it can contribute to science in terms of a new therapeutic treatment for endometriosis. Further studies are required to evaluate the Coenzyme Q10's effects on pain and subfertility in endometriosis.en_US
dc.description.sponsorshipProjects of Scientific Investigation at Gazi University [01/2019-17]en_US
dc.description.sponsorshipThis study was supported by the Projects of Scientific Investigation at Gazi University [grant number 01/2019-17].en_US
dc.identifier.doi10.1080/01443615.2022.2114322
dc.identifier.endpage3298en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7en_US
dc.identifier.pmid36048875en_US
dc.identifier.scopus2-s2.0-85137091388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3290en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2022.2114322
dc.identifier.urihttps://hdl.handle.net/20.500.14034/818
dc.identifier.volume42en_US
dc.identifier.wosWOS:000849763500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.journalJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoenzyme Q10en_US
dc.subjectendometriosisen_US
dc.subjectinfertilityen_US
dc.subjectVEGFen_US
dc.subjectMMP-9en_US
dc.subjectBreast-Canceren_US
dc.subjectModelen_US
dc.subjectRegressionen_US
dc.subjectSupplementationen_US
dc.subjectInflammationen_US
dc.subjectExplantsen_US
dc.subjectStressen_US
dc.subjectWomenen_US
dc.titleThe therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley ratsen_US
dc.typeArticleen_US

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