Radiomic phenotypes distinguish atypical teratoid/rhabdoid tumors from medulloblastoma
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Tarih
2021
Dergi Başlığı
Dergi ISSN
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Yayıncı
Amer Soc Neuroradiology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND AND PURPOSE: Atypical teratoid/rhabdoid tumors and medulloblastomas have similar imaging and histologic features but distinctly different outcomes. We hypothesized that they could be distinguished by MR imaging?based radiomic phenotypes. MATERIALS AND METHODS: We retrospectively assembled T2-weighted and gadolinium-enhanced T1-weighted images of 48 posterior fossa atypical teratoid/rhabdoid tumors and 96 match-paired medulloblastomas from 7 institutions. Using a holdout test set, we measured the performance of 6 candidate classifier models using 6 imaging features derived by sparse regression of 900 T2WI and 900 T1WI Imaging Biomarker Standardization Initiative?based radiomics features. RESULTS: From the originally extracted 1800 total Imaging Biomarker Standardization Initiative?based features, sparse regression consistently reduced the feature set to 1 from T1WI and 5 from T2WI. Among classifier models, logistic regression performed with the highest AUC of 0.86, with sensitivity, specificity, accuracy, and F1 scores of 0.80, 0.82, 0.81, and 0.85, respectively. The top 3 important Imaging Biomarker Standardization Initiative features, by decreasing order of relative contribution, included voxel intensity at the 90th percentile, inverse difference moment normalized, and kurtosis?all from T2WI. CONCLUSIONS: Six quantitative signatures of image intensity, texture, and morphology distinguish atypical teratoid/rhabdoid tumors from medulloblastomas with high prediction performance across different machine learning strategies. Use of this technique for preoperative diagnosis of atypical teratoid/rhabdoid tumors could significantly inform therapeutic strategies and patient care discussions.
Açıklama
Anahtar Kelimeler
Central-Nervous-System, Primitive Neuroectodermal Tumors, Teratoid Rhabdoid Tumors, Posterior-Fossa Tumors, Mri Features, Immunohistochemical Analysis, Craniospinal Radiotherapy, Children, Childhood, Infancy
