Effect of ondansetron for preventing of ovarian hyperstimulation syndrome: in an experimental rat model

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dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authoridsagsoz, nevin/0000-0002-9927-5877
dc.authoridGOZUYUKARI, Hilal/0000-0003-0282-2596
dc.contributor.authorBakirci, Suekrue
dc.contributor.authorSagsoez, Nevin
dc.contributor.authorDevrim, Tuba
dc.contributor.authorSahin, Yasar
dc.contributor.authorBulanik, Murat
dc.contributor.authorGoezueyukari, Hilal
dc.date.accessioned2023-03-22T19:47:26Z
dc.date.available2023-03-22T19:47:26Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractObjective: Ovarian hyperstimulation syndrome is an iatrogenic condition that occurs in the treatment of infertility. There is no specific treatment available for OHSS. Cabergoline is a dopamine receptor 2 agonist and VEGF-VEGF2 receptor antagonist . Recently, cabergoline has been widely used to prevent the development of OHSS and reduce its severity Serotonin is known as a neurotransmitter and thought to have a role in the mechanism of angiogenesis and in signaling in endothelial cells. Serotonin is said to have similar effects to VEGF . Ondansetron is Selective Serotonin (5-HT3) Receptor Antagonist . It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. In the clinical practice today, there is no choice other than cabergoline, to prevent occurrence and reduce severity of OHSS, and sometimes its effects are limited. Methods: In our study, we compared the effect of cabergoline and ondansetron. 32 immature rats were used and the OHSS model was created. Parameters such as hematocrit value , ovarian size, the number of follicles in the ovary, endometrial capillary congestion and thickness values were evaluated and compared. Results: As a result, in our study, it was seen that ondansetron was effective on OHSS in many parameters. It is thought to be as effective as cabergoline. When we look at the literature, this is the first study in which ondansetron was evaluated for this purpose. It would be good to show this effect of ondansetron with other studies.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2020/092]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Kirikkale University. Project number 2020/092en_US
dc.identifier.doi10.1080/09513590.2022.2163233
dc.identifier.endpage1096en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue12en_US
dc.identifier.pmid36579847en_US
dc.identifier.scopus2-s2.0-85145299864en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1093en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2022.2163233
dc.identifier.urihttps://hdl.handle.net/20.500.14034/697
dc.identifier.volume38en_US
dc.identifier.wosWOS:000905639200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.journalGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCabergolineen_US
dc.subjectondansetronen_US
dc.subjectovarian hyperstimulation syndromeen_US
dc.subjectrat modelen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectCabergolineen_US
dc.subjectPathophysiologyen_US
dc.subjectReceptorsen_US
dc.subjectSerotoninen_US
dc.titleEffect of ondansetron for preventing of ovarian hyperstimulation syndrome: in an experimental rat modelen_US
dc.typeArticleen_US

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