The role of sperm DNA integrity in couples with recurrent implantation failure following IVF treatment

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dc.authoridHORSANALI, Mustafa Ozan/0000-0002-3651-0948
dc.authoridCaglayan, Alper/0000-0001-6884-489X
dc.authorwosidHORSANALI, Mustafa Ozan/AAU-2142-2021
dc.authorwosidCaglayan, Alper/AAC-9373-2022
dc.contributor.authorÇağlayan, Alper
dc.contributor.authorHorsanalı, Mustafa Ozan
dc.contributor.authorBuyrukçu, Buğra Adil
dc.date.accessioned2023-03-22T19:47:40Z
dc.date.available2023-03-22T19:47:40Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractThere is increasing evidence from the literature that indicates the association between impaired sperm DNA integrity and male infertility. However, the data is insufficient regarding recurrent implantation failure (RIF) and sperm DNA damage. This study aimed to investigate the association between sperm DNA fragmentation and RIF cases. Basic semen parameters and sperm DNA fragmentation index (DFI) of men whose partner was suffering from RIF were compared with men whose partner was diagnosed with unexplained infertility (UEI) but had clinical pregnancies following IVF treatment. A retrospective analysis from a large-volume IVF center has been performed, and a total of 197 couples underwent analysis. Two groups were formed, couples with RIF and couples diagnosed with UEI but had clinical pregnancies (controls) following IVF cycles. The mean number of cycles showed significant differences between the groups. However, no statistical difference was observed between RIF and the control group regarding patient characteristics, semen parameters, and sperm DNA fragmentation index (DFI). Also, no statistically significant correlation was found between sperm DFI and clinical pregnancies in the unexplained infertility cohort. Our results show that sperm DNA fragmentation may not be an important contributing factor to RIF cases.en_US
dc.identifier.doi10.1111/and.14496
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.pmid35671775en_US
dc.identifier.scopus2-s2.0-85131324869en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.14496
dc.identifier.urihttps://hdl.handle.net/20.500.14034/816
dc.identifier.wosWOS:000808092600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectin vitro fertilizationen_US
dc.subjectrecurrent implantation failureen_US
dc.subjectsperm DNA fragmentationen_US
dc.subjectunexplained infertilityen_US
dc.subjectFragmentation Indexen_US
dc.subjectEmbryo Qualityen_US
dc.subjectIntrauterine Inseminationen_US
dc.subjectHuman Spermatozoaen_US
dc.subjectPregnancy Ratesen_US
dc.subjectStrand Breaksen_US
dc.subjectIn-Vitroen_US
dc.subjectFertilityen_US
dc.subjectAssayen_US
dc.subjectFertilizationen_US
dc.titleThe role of sperm DNA integrity in couples with recurrent implantation failure following IVF treatmenten_US
dc.typeArticleen_US

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