Transauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model

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dc.authoridatalar, kerem/0000-0003-1239-1144
dc.authoridBAHCELIOGLU, Meltem/0000-0001-5279-3450
dc.contributor.authorAtalar, Kerem
dc.contributor.authorAlim, Ece
dc.contributor.authorYigman, Zeynep
dc.contributor.authorBelen, Hayrunnisa Bolay
dc.contributor.authorErten, Fusun
dc.contributor.authorSahin, Kazim
dc.contributor.authorSoylu, Ayse
dc.date.accessioned2025-03-20T09:50:47Z
dc.date.available2025-03-20T09:50:47Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractInflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), is a major health problem on a global scale and its treatment is unsatisfactory. We aimed to investigate the effects of transauricular vagal nerve stimulation (tVNS) on inflammation in rats with IBD induced by trinitrobenzene sulfonic acid (TNBS). A total of 36 adult female Sprague-Dawley rats were given TNBS, or vehicle, and tVNS, or sham, every other day for 30 min for 10 days. Postmortem macroscopic and microscopic colon morphology were evaluated by histological staining. Additionally, IL-1 beta, IL-6, IL-10, and TNF-alpha cytokine levels in the colon and the brain were evaluated by immunohistochemistry and western blotting analysis. TNBS induced epithelial damage, inflammation, ulceration, and thickened mucosal layer in the colonic tissues. Administration of tVNS significantly ameliorated the severity of TNBS-induced tissue damage and inflammatory response. TNBS also alters pro-inflammatory and anti-inflammatory balance in the brain tissue. TVNS application significantly suppressed the protein levels of pro-inflammatory cytokines, namely IL-1 beta, IL-6, and TNF- alpha while augmenting the level of anti-inflammatory cytokine IL-10 in the colonic and the brain tissue. We have shown that TNBS-mediated colonic inflammation and tissue damage are associated with neuroinflammatory responses in the brain tissue. Also demonstrated for the first time that neuroinflammatory response in the gut-brain axis is suppressed by tVNS in the IBD model. Non-invasive tVNS stands out as a new potential treatment option for types of IBD.
dc.description.sponsorshipGazi University Scientific Research Projects Coordination Unit [TTU-2021-7301]
dc.description.sponsorshipGazi University Scientific Research Projects Coordination Unit, Grant/Award N u m b e r : TTU-2021-7301.
dc.identifier.doi10.1111/joa.14178
dc.identifier.issn0021-8782
dc.identifier.issn1469-7580
dc.identifier.pmid39707162
dc.identifier.scopus2-s2.0-85215567865
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/joa.14178
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2315
dc.identifier.wosWOS:001380612900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Anatomy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectIL-1 beta
dc.subjectIL-10
dc.subjectIL-6
dc.subjectinflammatory bowel disease
dc.subjectTNBS
dc.subjectTNF-alpha
dc.subjectTransauricular vagal nerve stimulation
dc.titleTransauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model
dc.typeArticle

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