Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materialsUntersuchung der kontrollierten Wirkstofffreisetzung von Ibuprofen mit präparierten und charakterisierten innovativen Bigel-Materialien

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dc.authoridMutlu, Dogukan/0000-0003-3259-5822
dc.contributor.authorKizilhan, E.
dc.contributor.authorOzcan, Y.
dc.contributor.authorErden Gonenmis, D.
dc.contributor.authorMutlu, D.
dc.contributor.authorGok, C.
dc.contributor.authorArslan, S.
dc.date.accessioned2024-03-09T18:48:13Z
dc.date.available2024-03-09T18:48:13Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractNew systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by in vitro studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth-order, first-order, Higuchi, and Korsmeyer-Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer-Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism. Created bigels with controlled ibuprofen release using span 40, alginate, centaury oil, black cumin oil, and sorbitan monopalmitate. Spectroscopic and thermal analyze techniques were used to characterize. The bigels have been a potential alternative material for controlled drug delivery systems because of their biocompatibility, slower drug release, and diffusion release mechanism.imageen_US
dc.description.sponsorshipScientific Research Council of Pamukkale University, Turkiye [2021FEBE011]; Scientific Research Council of Pamukkale Universityen_US
dc.description.sponsorshipThe authors would like to thank the Scientific Research Council of Pamukkale University, Turkiye, for research grant 2021FEBE011.en_US
dc.identifier.doi10.1002/mawe.202300045
dc.identifier.endpage1716en_US
dc.identifier.issn0933-5137
dc.identifier.issn1521-4052
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85180683152en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1707en_US
dc.identifier.urihttps://doi.org/10.1002/mawe.202300045
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1217
dc.identifier.volume54en_US
dc.identifier.wosWOS:001138603900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMaterialwissenschaft Und Werkstofftechniken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBigel; Controlled Drug Release; Hydrogel; Ibuprofen; Organogel; Bigel; Hydrogel; Ibuprofen; Kontrollierte Medikamentenfreisetzung; Organogelen_US
dc.titleInvestigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materialsUntersuchung der kontrollierten Wirkstofffreisetzung von Ibuprofen mit präparierten und charakterisierten innovativen Bigel-Materialienen_US
dc.typeArticleen_US

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