Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materialsUntersuchung der kontrollierten Wirkstofffreisetzung von Ibuprofen mit präparierten und charakterisierten innovativen Bigel-Materialien
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Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
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Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by in vitro studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth-order, first-order, Higuchi, and Korsmeyer-Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer-Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism. Created bigels with controlled ibuprofen release using span 40, alginate, centaury oil, black cumin oil, and sorbitan monopalmitate. Spectroscopic and thermal analyze techniques were used to characterize. The bigels have been a potential alternative material for controlled drug delivery systems because of their biocompatibility, slower drug release, and diffusion release mechanism.image
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Anahtar Kelimeler
Bigel; Controlled Drug Release; Hydrogel; Ibuprofen; Organogel; Bigel; Hydrogel; Ibuprofen; Kontrollierte Medikamentenfreisetzung; Organogel
