Psychopharmacological signatures in the retina in schizophrenia and bipolar disorder: an optic coherence tomography study

Basit Öğe Kaydı
dc.authoridAtagun, Murat Ilhan / 0000-0002-8514-0576
dc.authorscopusid57191329477
dc.authorscopusid57221412158
dc.authorscopusid36118578900
dc.authorscopusid54792689200
dc.authorwosidAtagun, Murat Ilhan/ABA-6588-2021
dc.contributor.authorAltun, İlkay Keleş
dc.contributor.authorTuredi, Neslihan
dc.contributor.authorAras, Neriman
dc.contributor.authorAtagün, Murat İlhan
dc.date.accessioned2022-02-15T16:57:19Z
dc.date.available2022-02-15T16:57:19Z
dc.date.issued2020
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground: Retina is considered as a window to the brain due to the similarities in terms of development and pathologies. Optical coherence tomography (OCT) can perform quantitative examinations in the retina. In this study, we aimed to investigate the effects of drugs used in schizophrenia and bipolar disorder (BD) on retinal nerve fiber layer (RNFL) and macular thickness. Subjects and methods: The study included schizophrenia (n=35) and euthymic BD (n=46) patients on various medications, and age, gender matched healthy control group (n=31). For retinal evaluation, measurements of RNFL and macula were performed with Optovue RTVue Premier OCT. Results: In the schizophrenia group, chlorpromazine equivalent dose of antipsychotics was a statistically significant negative predictor of left RNFL nasal superior region thickness. In the BD group, serum valproate level was a significant positive predictor of thickness in the right macular inferior outer, left macular nasal outer region, right RNFL inferotemporal, left temporal and inferotemporal regions. Conclusion: Since the retina consists of neurons, morphological or functional examination of retina may be beneficial for the evaluation of the effects of psychopharmalogical treatments in schizophrenia and BD. The outcome of this study implies that valproate has neuroprotective effects on the optic nerve and macula, and this finding is consistent with the literature implying neurotrophic effects of valproate.en_US
dc.identifier.doi10.24869/psyd.2020.351
dc.identifier.endpage358en_US
dc.identifier.issn0353-5053
dc.identifier.issue3-4en_US
dc.identifier.pmid33370732en_US
dc.identifier.scopus2-s2.0-85099103535en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.24869/psyd.2020.351
dc.identifier.urihttps://hdl.handle.net/20.500.14034/94
dc.identifier.volume32en_US
dc.identifier.wosWOS:000641746300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.journalPsychiatria Danubinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectschizophreniaen_US
dc.subjectbipolar disorderen_US
dc.subjectretinaen_US
dc.subjectvalproateen_US
dc.subjectantipsychoticsen_US
dc.subjectNerve-Fiber Layeren_US
dc.subjectBrain Volumeen_US
dc.subjectMetaanalysisen_US
dc.subjectThicknessen_US
dc.subjectDeficitsen_US
dc.subjectDiseaseen_US
dc.subjectAbnormalitiesen_US
dc.titlePsychopharmacological signatures in the retina in schizophrenia and bipolar disorder: an optic coherence tomography studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Psychopharmacological signatures in the retina in schizophrenia and.pdf
Boyut:
127.29 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu