The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures

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dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authoridKaraarslan, Numan/0000-0001-5590-0637
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.contributor.authorCaliskan, Tezcan
dc.contributor.authorAkalan, Hande
dc.contributor.authorYilmaz, Ibrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorSirin, Duygu Yasar
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2023-03-22T19:47:38Z
dc.date.available2023-03-22T19:47:38Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractIntroduction: The present study aimed to investigate the potential effects of rivaroxaban, an oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells and the extracellular matrix (ECM). Material and methods: Rivaroxaban was applied to primary human cell cultures prepared from tissues of the intervertebral disc. Comparative molecular analyses were performed on non-drug-treated control group samples. Descriptive statistics were presented as the mean +/- standard deviation. An analysis of variance test was performed to determine whether there were significant differences in the mean across the groups. When differences across groups were observed, Tukey's honestly significant difference post-hoc test was used for multiple pairwise comparisons. The significance of the obtained data was determined statistically. The alpha significance value was < 0.05. Results: The cells in the control group and in the rivaroxaban-treated group were viable, healthy, and proliferated (p < 0.05). However, the expression levels of the chondroadherin gene (CHAD), cartilage oligo matrix protein (COMP), matrix metalloproteinase (MMP)-13, and MMP-19 genes were changed (p < 0.05). Conclusions: Although rivaroxaban does not suppress cell proliferation due to morphological, biological, and biochemical changes in the intervertebral disc tissue, it may change the expression of genes that are related to ECM maintenance.en_US
dc.identifier.doi10.5114/aoms/136323
dc.identifier.endpage1070en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue4en_US
dc.identifier.pmid35832710en_US
dc.identifier.scopus2-s2.0-85134502556en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1062en_US
dc.identifier.urihttps://doi.org/10.5114/aoms/136323
dc.identifier.urihttps://hdl.handle.net/20.500.14034/800
dc.identifier.volume18en_US
dc.identifier.wosWOS:000821077400017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.journalArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcartilage oligo matrix proteinen_US
dc.subjectchondroadherin geneen_US
dc.subjectcytotoxicityen_US
dc.subjectintervertebral disc cellsen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectnucleus pulposusen_US
dc.subjectrivaroxabanen_US
dc.subjectOligomeric Matrix Proteinen_US
dc.subjectHippocampal Tissueen_US
dc.subjectMetalloproteinasesen_US
dc.subjectInhibitoren_US
dc.titleThe effects of rivaroxaban, an oral anticoagulant, on human IVD primary culturesen_US
dc.typeArticleen_US

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