Evaluation of cardiovascular disease risk factors, inflammatory markers and subclinical atherosclerosis in patients with hemophilia

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dc.contributor.authorBozgül, Şükriye Miray Kılınçer
dc.contributor.authorTürk, Uğur Önsel
dc.contributor.authorSaydam, Güray
dc.contributor.authorBarutcuoğlu, Burcu
dc.contributor.authorŞahin, Fahri
dc.contributor.authorAtilla, Fatoş Dilan
dc.contributor.authorAk, Güneş
dc.date.accessioned2023-03-22T19:48:25Z
dc.date.available2023-03-22T19:48:25Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractAim: To assess and compare the risk factors of cardiovascular disease (CVD) between patients with hemophilia (PwH) and healthy controls in a single center cohort in Türkiye. Materials and Methods: Anthropometric parameters including height, weight, and body mass index were recorded. Fasting glucose, HbA1c, high sensitive C-Reactive Protein (hs-CRP), adiponectin, lipid parameters (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) were assessed. International Physical Activity Questionnaires (IPAQ) and carotid intima media thickness (CIMT) measurements were performed. The data from PwH (n=80) and healthy controls (n=36) were compared. Independent associates of CIMT value were analyzed. Results: Hypertension, diabetes mellitus, metabolic syndrome and smoking frequencies were remarkable in PwH. Family history of CVD was significantly more frequent ( p=0.005) and when considered with IPAQ scores; PwH was much more sedentary than controls (p<0.001). Total cholesterol, LDL-cholesterol were significantly higher in the control group (p =0.003,=0.003) while hs CRP levels were higher in PwH (p=0.009). Age and IPAQ score were significant independent predictors of CIMT (p=0.004 and 0.003, respectively). Conclusion: As a result of aging; PwH exposure to the same CVD risk factors as the general population. Screening for CVD risk factors in PwH other than hemophilia evaluation will be essential.en_US
dc.identifier.endpage557en_US
dc.identifier.issn1016-9113
dc.identifier.issn2147-6500
dc.identifier.issue4en_US
dc.identifier.startpage549en_US
dc.identifier.trdizinid1143328en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1088
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1143328
dc.identifier.volume61en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.journalEge Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of cardiovascular disease risk factors, inflammatory markers and subclinical atherosclerosis in patients with hemophiliaen_US
dc.typeArticleen_US

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