Splenic Artery Doppler Waveforms in Gestational Diabetes and Association with Fetal Pancreas: A Prospective Case-Control Study

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dc.authoridEkin, Atalay/0000-0002-4712-3927
dc.authoridGolbasi, Hakan/0000-0001-8682-5537
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorBayraktar, Burak
dc.contributor.authorGolbasi, Ceren
dc.contributor.authorOmeroglu, Ibrahim
dc.contributor.authorCakir, Zubeyde Emiralioglu
dc.contributor.authorCan, Sevim Tuncer
dc.contributor.authorPehlivanoglu, Osman Caglar
dc.date.accessioned2025-03-20T09:50:46Z
dc.date.available2025-03-20T09:50:46Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractIntroduction: This study evaluated fetal pancreas size and echogenicity, and splenic artery (SA) waveforms in pregnant women with gestational diabetes mellitus (GDM). Methods: This prospective case-control study was performed from October 2022 to November 2023 and included 124 pregnant women (62 with GDM and 62 controls). Pancreatic circumference, pancreatic echogenicity, umbilical artery Doppler measurements (systolic/diastolic ratio [S/D] and pulsatility index [PI]), SA Doppler measurements (S/D, PI, peak systolic velocity [PSV], time-averaged maximum velocity, and pressure gradient [PG] mean and maximum) values were compared between the GDM and control groups. Results: The mean pancreatic circumference was higher and grade 2/3 echogenicity was more common in the GDM group, while grade 1 echogenicity was more common in the control group (p < 0.001 and p < 0.001, respectively). SA S/D and PI measurements were significantly higher in the GDM group than in the control group (p < 0.001 and p = 0.001, respectively). Moreover, PG(max) was significantly higher in the GDM group than in the control group (p = 0.038). Pancreatic circumference was positively correlated with SA PSV (p = 0.004). Additionally, pancreatic circumference was positively correlated with PG(mean) and PG(max) (p = 0.010 and p = 0.016, respectively). The increase in pancreas echogenicity was positively correlated with SA S/D and PI measurements (p = 0.007 and p = 0.002, respectively). PG(max) was also positively correlated with increased pancreas echogenicity (p = 0.023). Conclusion: This study showed that fetal pancreas size and echogenicity were significantly higher in pregnant women with GDM than in controls. SA Doppler waveforms were consistent with an increase in vascular resistance associated with elevations of both S/D and PI in the GDM group.
dc.identifier.doi10.1159/000539585
dc.identifier.endpage509
dc.identifier.issn1015-3837
dc.identifier.issn1421-9964
dc.identifier.issue5
dc.identifier.pmid38815567
dc.identifier.scopus2-s2.0-85205603783
dc.identifier.scopusqualityQ1
dc.identifier.startpage500
dc.identifier.urihttps://doi.org/10.1159/000539585
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2302
dc.identifier.volume51
dc.identifier.wosWOS:001328781600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofFetal Diagnosis and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectSplenic artery
dc.subjectGestational diabetes
dc.subjectFetal pancreas
dc.subjectDoppler ultrasonography
dc.titleSplenic Artery Doppler Waveforms in Gestational Diabetes and Association with Fetal Pancreas: A Prospective Case-Control Study
dc.typeArticle

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