Evaluation of Oxidative System Parameters in Alzheimer's Disease Before Medical Treatment

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dc.authoridGuleken, ZOZAN/0000-0002-4136-4447
dc.authorwosidGuleken, ZOZAN/AAF-1789-2019
dc.contributor.authorAyada, Ceylan
dc.contributor.authorErbay, Umran Toru
dc.contributor.authorKorkut, Yasemin
dc.contributor.authorGuleken, Zozan
dc.contributor.authorOner, Zulal
dc.date.accessioned2023-03-22T19:47:27Z
dc.date.available2023-03-22T19:47:27Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground: Alzheimer's disease (AD) is the most common reason for dementia and is one of the most important causes of morbidity and mortality in the aging population. A crucial component of AD is the brain's sensitivity to oxidative stress. We aimed to determine the oxidative load of patients with AD who had just been diagnosed and had not yet begun medical treatment.Methods: To assess oxidative load before drug administration, we compared the levels of serum total antioxidant (TAS), oxidant status (TOS), paraoxonase (PON1), arylesterase (ARES), total thiol (THIOL) levels in patients just diagnosed with AD (n = 41) and control (n = 45) with the totally 86 individuals. AD and control groups oxidative stress index (OSI) ratio was calculated too.Results: There was a statistically significant difference between the AD and control groups for mean TAS, TOS, and OSI levels with a 95% confidence level (pTAS = 0.001, pTOS = 0.005, pOSI = 0.001). There was not a statistically significant difference between the groups in terms of mean PON1, ARES, and THIOL values. Significantly negative and positive correlations were found for the interested parameters in both groups.Conclusion: The increase in antioxidative capacity in patients with AD may be related to ARES supported by TAS, and THIOL levels suggest, that those protein oxidation mechanisms are effective in the progress of AD disease before medication.Copyright (c) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.en_US
dc.identifier.doi10.6890/IJGE.202210_16(4).0016
dc.identifier.endpage399en_US
dc.identifier.issn1873-9598
dc.identifier.issn1873-958X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85150248037en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.6890/IJGE.202210_16(4).0016
dc.identifier.urihttps://hdl.handle.net/20.500.14034/707
dc.identifier.volume16en_US
dc.identifier.wosWOS:000888027600017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTaiwan Soc Geriatric Emergency & Critical Care Medicine-Tsgecmen_US
dc.relation.journalInternational Journal Of Gerontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer?s diseaseen_US
dc.subjectarylesteraseen_US
dc.subjectparaoxonaseen_US
dc.subjecttotal oxidative stressen_US
dc.subjecttotal thiolen_US
dc.subjectOxidant/Antioxidant Statusen_US
dc.subjectGene Polymorphismsen_US
dc.subjectStressen_US
dc.subjectRadicalsen_US
dc.subjectAssociationen_US
dc.subjectImpairmenten_US
dc.subjectBiomarkersen_US
dc.subjectImbalanceen_US
dc.subjectDementiaen_US
dc.subjectPlasmaen_US
dc.titleEvaluation of Oxidative System Parameters in Alzheimer's Disease Before Medical Treatmenten_US
dc.typeArticleen_US

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