Does Duke Activity Status Index help predicting functional exercise capacity and long-term prognosis in patients with pulmonary hypertension?

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dc.authoridASLAN, GOKSEN KURAN / 0000-0002-0169-0707
dc.authoridMustafaoglu, Rustem / 0000-0001-7030-0787
dc.authoridZeren, Melih / 0000-0002-9749-315X
dc.authorscopusid57189065953
dc.authorscopusid7006161415
dc.authorscopusid56180876200
dc.authorscopusid55364192200
dc.authorscopusid57192204790
dc.authorscopusid6603550419
dc.authorwosidASLAN, GOKSEN KURAN/ABC-4834-2021
dc.authorwosidMustafaoglu, Rustem/E-3412-2019
dc.contributor.authorMustafaoğlu, Rüstem
dc.contributor.authorDemir, Rengin
dc.contributor.authorAslan, Gökşen Kuran
dc.contributor.authorSinan, Ümit Yaşar
dc.contributor.authorZeren, Melih
dc.contributor.authorKüçükoğlu, Mehmet Serdar
dc.date.accessioned2022-02-15T16:58:09Z
dc.date.available2022-02-15T16:58:09Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground: To investigate the association of Duke Activity Status Index (DASI) with 6-minute walk test (6MWT) and WHO-Functional Class (WHO-FC) in patients with pulmonary hypertension (PH), as well as exploring whether DASI can discriminate between the patients with better and worse long-term prognosis according to 400 m cut-off score in 6MWT. Methods: Eighty-five medically stable PH patients who met eligibility criteria were included. All patients were evaluated using 6MWT and DASI. The prognostic utility of the DASI was assessed using univariate linear regression and receiver operating characteristic (ROC) curve analysis. Results: The DASI was an independent predictor for both 6MWT and WHO-FC, explaining 50% of variance in 6MWT and 30% of variance in WHO-FC class (p < 0.001). In addition, DASI significantly correlated to 6MWT (r = 0.702) and WHO-FC class (r = 0.547). The ROC curve analysis revealed that the DASI had a discriminative value for identifying the patients with better long-term prognosis (p < 0.001), with an area under ROC curve of 0.867 [95% CI = 0.782-0.952]. The DASI >= 26 was the optimal cut-off value for better long-term prognosis, having sensitivity of 0.74 and a specificity of 0.88. Conclusions: The DASI is a valid tool reflecting functional exercise capacity in patients with PH. Considering its ability to discriminate between the patients with better or worse long-term prognosis, it may help identifying the patients at higher risk.en_US
dc.identifier.doi10.1016/j.rmed.2021.106375
dc.identifier.issn0954-6111
dc.identifier.issn1532-3064
dc.identifier.pmid33799051en_US
dc.identifier.scopus2-s2.0-85103343973en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2021.106375
dc.identifier.urihttps://hdl.handle.net/20.500.14034/356
dc.identifier.volume181en_US
dc.identifier.wosWOS:000655213100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.journalRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectFunctional exercise capacityen_US
dc.subjectDASIen_US
dc.subject6MWTen_US
dc.subject6-Minute Walk Testen_US
dc.subjectQuality-Of-Lifeen_US
dc.subjectArterial-Hypertensionen_US
dc.subjectHeart-Failureen_US
dc.subjectNoncardiac Surgeryen_US
dc.subjectSurvivalen_US
dc.subjectAssociationen_US
dc.subjectGuidelinesen_US
dc.subjectDiagnosisen_US
dc.subjectManagementen_US
dc.titleDoes Duke Activity Status Index help predicting functional exercise capacity and long-term prognosis in patients with pulmonary hypertension?en_US
dc.typeArticleen_US

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