Can the cell-free DNA test predict placenta accreta spectrum or placenta previa totalis?

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dc.authoridOztekin, Deniz / 0000-0002-4213-7254
dc.authoridAdiyaman, Duygu / 0000-0002-5307-8149
dc.authorscopusid57212208266
dc.authorscopusid56496982000
dc.authorscopusid57195107995
dc.authorscopusid57242787900
dc.authorscopusid6701864757
dc.authorscopusid23995432100
dc.authorscopusid57193450671
dc.authorwosidOztekin, Deniz/AAT-3898-2021
dc.contributor.authorAdıyaman, Duygu
dc.contributor.authorKuyucu, Melda
dc.contributor.authorAtakul, Bahar Konuralp
dc.contributor.authorCan, Dilara
dc.contributor.authorÖzeren, Mehmet
dc.contributor.authorKoç, Altuğ
dc.contributor.authorÖztekin, Deniz
dc.date.accessioned2022-02-15T16:57:16Z
dc.date.available2022-02-15T16:57:16Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractBackground Following the discovery that fetal DNA originates from the trophoblastic cells of the placenta, the contribution of the cell-free DNA test in placenta-related obstetric complications has begun to be investigated. Compared to uncomplicated pregnancies, higher fetal fractions were detected in placenta accreta spectrum and placenta previa, which are among placenta-related obstetric complications. However, this data applies only to advanced gestational weeks. Aim To investigate the possible predictive value of fetal fraction in cell-free DNA tests in pregnancies with placenta previa and placenta accreta spectrum in early gestational ages. Materials and Methods This study was conducted in women who were screened via cell-free DNA tests for common aneuploidies in the first and second trimester and subsequently diagnosed with placenta previa or placenta accreta spectrum. After the diagnosis was confirmed with a C-section, fetal fractions were retrospectively compared to a control group with a history of an uncomplicated C-section who were also previously screened by cell-free DNA test. Results The median and interquartile range (IQR) of fetal fractions for placenta previa (n=19), placenta accreta spectrum (n=7), and control groups (n=85) were 8.1 (6-10), 6.8 (6.7-10.7), and 7.1 (4.7-9.65), respectively. No statistically significant difference was observed among the three groups in terms of fetal fractions (p=0.587). Conclusions According to our data, we did not observe any relationship between placental invasion abnormalities vs. control group or placenta previa vs. control group using the fetal fractions of the cell-free DNA test. Furthermore, we could not confirm a predictive role and/or any additional clinical contribution. We believe that future studies focusing on placental mRNA might be more helpful than cell-free fetal DNA testing.en_US
dc.identifier.doi10.1055/a-1579-1338
dc.identifier.issn0948-2393
dc.identifier.issn1439-1651
dc.identifier.pmid34433209en_US
dc.identifier.scopus2-s2.0-85114092260en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1055/a-1579-1338
dc.identifier.urihttps://hdl.handle.net/20.500.14034/59
dc.identifier.wosWOS:000688207700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.journalZeitschrift Fur Geburtshilfe Und Neonatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcell-free DNA testen_US
dc.subjectfetal fractionen_US
dc.subjectplacenta accreta spectrumen_US
dc.subjectplacenta previaen_US
dc.subjectFree Fetal Dnaen_US
dc.subjectMaternal Plasmaen_US
dc.subjectPregnanciesen_US
dc.subjectFractionen_US
dc.subjectHealthen_US
dc.titleCan the cell-free DNA test predict placenta accreta spectrum or placenta previa totalis?en_US
dc.typeArticleen_US

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