Expression levels of tam receptors and ligands in the testes of rats exposed to short and middle-term 2100 MHz radiofrequency radiation

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dc.authoridKATIRCI, ERTAN/0000-0002-3781-9162
dc.authoridKirimlioglu, Esma/0000-0002-5689-5670
dc.authoridHidisoglu, Enis/0000-0002-1729-1209
dc.contributor.authorKatirci, Ertan
dc.contributor.authorKirimlioglu, Esma
dc.contributor.authorOflamaz, Asli O.
dc.contributor.authorHidisoglu, Enis
dc.contributor.authorCernomorcenco, Alexandra
dc.contributor.authorYargicoglu, Piraye
dc.contributor.authorOzen, Sukru
dc.date.accessioned2025-03-20T09:51:26Z
dc.date.available2025-03-20T09:51:26Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractWith advances in technology, the emission of radiofrequency radiation (RFR) into the environment, particularly from mobile devices, has become a growing concern. Tyro 3, Axl, and Mer (TAM) receptors and their ligands are essential for spermatogenesis and testosterone production. RFR has been shown to induce testicular cell apoptosis by causing inflammation and disrupting homeostasis. This study aimed to investigate the role of TAM receptors and ligands in the maintenance of homeostasis and elimination of apoptotic cells in the testes (weeks), short-term sham exposure (sham/1 week), and middle-term sham exposure (sham/10 weeks). Testicular morphology was assessed using hematoxylin-eosin staining, while immunohistochemical staining was performed to assess expression levels of TAM receptors and ligands in the testes of all groups. The results showed that testicular morphology was normal in the control, sham/1 week, and sham/10 weeks groups. However, abnormal processes of spermatogenesis and seminiferous tubule morphology were observed in RFR exposure groups. Cleaved Caspase 3 immunoreactivity showed statistically significant difference in 1 and 10 weeks exposure groups compared to control group. Moreover, there was no significant difference in the immunoreactivity of Tyro 3, Axl, Mer, Gas 6, and Pros 1 between groups. Moreover, Tyro 3 expression in Sertoli cells was statistically significantly increased in RFR exposure groups compared to the control. Taken together, the results suggest that RFR exposure negatively affects TAM signalling, preventing the clearance of apoptotic cells, and this process may lead to infection and inflammation. As a result, rat testicular morphology and function may be impaired. Exposure to radiofrequency radiation (RFR) disrupts normal seminiferous tubule morphology. RFR exposure in round spermatids may induce apoptosis independent of Tyro 3, Axl, and Mer (TAM) receptors. TAM receptors and ligands are expressed in rat testis.
dc.description.sponsorshipAkdeniz niversitesi; Akdeniz University Scientific Research Projects Coordination Unit; Antalya University Support Foundation
dc.description.sponsorshipThis study was supported by the Akdeniz University Scientific Research Projects Coordination Unit, project number TSA-2020-5431. The authors are grateful to the Akdeniz University Scientific Research Projects Coordination Unit for the grant. Moreover, the authors thank the Antalya University Support Foundation.
dc.identifier.doi10.1002/bem.22504
dc.identifier.endpage248
dc.identifier.issn0197-8462
dc.identifier.issn1521-186X
dc.identifier.issue5
dc.identifier.pmid38725116
dc.identifier.scopus2-s2.0-85192545148
dc.identifier.scopusqualityQ2
dc.identifier.startpage235
dc.identifier.urihttps://doi.org/10.1002/bem.22504
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2543
dc.identifier.volume45
dc.identifier.wosWOS:001216584100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBioelectromagnetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectradiofrequency radiation
dc.subjectrat
dc.subjectTAM receptors and ligands
dc.subjecttestis
dc.titleExpression levels of tam receptors and ligands in the testes of rats exposed to short and middle-term 2100 MHz radiofrequency radiation
dc.typeArticle

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