Effects of sulthiame on seizure frequency and EEG in children with electrical status epilepticus during slow sleep

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dc.authoridTekin, Hande Gazeteci / 0000-0002-4407-164X
dc.authorscopusid42062598700
dc.authorscopusid56592297600
dc.authorscopusid25222311100
dc.authorscopusid34567997900
dc.authorscopusid6701629782
dc.authorwosidTekin, Hande Gazeteci/AAV-4674-2021
dc.contributor.authorTopcu, Yasemin
dc.contributor.authorKılıç, Betül
dc.contributor.authorTekin, Hande Gazeteci
dc.contributor.authorAydın, Kürşad
dc.contributor.authorTuranlı, Güzide
dc.date.accessioned2022-02-15T16:58:41Z
dc.date.available2022-02-15T16:58:41Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractObjective: It is argued that early and adequate treatment of electrical status epilepticus in sleep (ESES) is essential to preserve cognitive functions and possibly recovering lost skills. Although antiepileptic drugs (AEDs) are effective in ESES, there is not much experience in the use of sulthiame. In this study, we aimed to examine the efficiency and tolerability of sulthiame in ESES. Methods: The data of 39 patients diagnosed as ESES and who received sulthiame as an additional treatment between 2016 and 2020 were reviewed retrospectively. Electroencephalographic (EEG) findings and seizure rates were compared before and after the sulthiame treatment. Results: The mean age was 8.5 +/- 4.1 (1.5-16 years). Nine out of 39 patients had benign childhood focal epilepsies. Structural causes were identified in 13 patients. The mean duration of sulthiame use was 32.5 +/- 13.7 months. After sulthiame treatment, 25 patients (64.1%) were seizure free, and 8 (20.5%) had more than a 50% decrease in seizure frequency. The mean seizure-free time after the sulthiame treatment was 27.8 +/- 17.9 months. Nineteen patients (48.7%) had complete, and nine patients (23.1%) had partial EEG improvement. Complete seizure control was significantly higher in benign focal epilepsy of childhood (p = 0.01). Significant neurocognitive and behavioral recovery, improvement in school performance was observed following sulthiame treatment (p < 0.001). Conclusion: Sulthiame was found to be effective in seizure control and EEG improvement in ESES. We think that the use of sulthiame alone can be a good choice with high efficacy and tolerability in ESES. (C) 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.yebeh.2021.107793
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.pmid33549940en_US
dc.identifier.scopus2-s2.0-85100382295en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.yebeh.2021.107793
dc.identifier.urihttps://hdl.handle.net/20.500.14034/451
dc.identifier.volume116en_US
dc.identifier.wosWOS:000617709000048en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.journalEpilepsy & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulthiameen_US
dc.subjectElectrical status epilepticus during slow sleepen_US
dc.subjectEEGen_US
dc.subjectSeizureen_US
dc.subjectChildrenen_US
dc.titleEffects of sulthiame on seizure frequency and EEG in children with electrical status epilepticus during slow sleepen_US
dc.typeArticleen_US

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