The effect of krill oil on Wnt/ß-catenin signaling pathway in acetaminopheninduced acute liver injury in mice

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dc.authoridEkici, Husamettin/0000-0001-6403-737X
dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authorwosidEkici, Husamettin/ADZ-1494-2022
dc.contributor.authorSahin, Yasar
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorSenol, Ali
dc.contributor.authorEkici, Husamettin
dc.contributor.authorDevrim, Tuba
dc.contributor.authorSudagidan, Mert
dc.date.accessioned2024-03-09T18:48:43Z
dc.date.available2024-03-09T18:48:43Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractObjectives: This study investigated the effect of krill oil (KO) on liver damage caused by acetaminophen (APAP). Methods: In the present study, the control and APAP groups were given distilled water by gavage for 14 days. In addition, the KO and APAP+KO groups were given 500 mg/kg krill oil by gavage for 14 days. At the end of 14 days, 0.9 % sodium chloride solution (saline solution) administration was applied intraperitoneally to the control and KO groups. Meanwhile, 220 mg/kg acetaminophen was administered to the APAP and APAP+KO groups. While some biochemical parameters in plasma were examined, some oxidative stress parameters in plasma and liver tissue were evaluated. Apoptotic and inflammatory responses of some primer sequences determined by quantitative Real-Time PCR (qPCR) in liver tissue. After histopathological examination of liver tissue, immunohistochemical analysis was performed with Wnt inhibitory factor-1 (Wif-1), beta-catenin (ss-Catenin), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Results: The Wif-1 positivity in hepatocytes increased significantly in the APAP group (5.29 +/- 0.71) compared to the control (1.14 +/- 0.51), and KO (2.14 +/- 0.55) groups (p<0.001). The 8-OHdG positivity in hepatocytes increased significantly in the APAP group (19.57 +/- 0.58) compared to the control (0.43 +/- 0.20), KO (3.57 +/- 0.48), and APAP+KO (4.00 +/- 2.53) groups (p<0.001). Conclusions: As a result, krill oil could be used as a nutritional supplement to protect the liver against acetaminopheninduced liver injury.en_US
dc.identifier.doi10.1515/tjb-2022-0289
dc.identifier.endpage271en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85170435725en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage264en_US
dc.identifier.trdizinid1251874
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0289
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1433
dc.identifier.volume48en_US
dc.identifier.wosWOS:000995739700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetaminophen; Acute Liver Injury; Krill Oil; Oxidative Stress; Qpcren_US
dc.titleThe effect of krill oil on Wnt/ß-catenin signaling pathway in acetaminopheninduced acute liver injury in miceen_US
dc.typeArticleen_US

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