Does venipuncture increase lymphedema by triggering inflammation or infection? An experimental rabbit ear lymphedema model study

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dc.authoridOzdemir, Kadirhan/0000-0002-0486-6878
dc.authoridDiker, Seyda/0000-0002-6018-2892
dc.authoridCitaker, Seyit/0000-0002-4215-6797
dc.authorwosidOzdemir, Kadirhan/ABC-8280-2020
dc.contributor.authorÖzdemir, Kadirhan
dc.contributor.authorÇıtaker, Seyit
dc.contributor.authorDiker, Şeyda
dc.contributor.authorKeser, İlke
dc.contributor.authorKurukahvecioglu, Osman
dc.contributor.authorUyar Göçün, Pinar
dc.contributor.authorGülbahar, Özlem
dc.date.accessioned2023-03-22T19:47:25Z
dc.date.available2023-03-22T19:47:25Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground: Recent guidelines recommend avoiding venipuncture to prevent lymphedema for breast cancer patients. This study investigated whether single or multiple sterile venipuncture procedures develop a systemic inflammation or infection and increase lymphedema in the rabbit ear lymphedema model.Methods and Results: Eighteen New Zealand white female rabbits were included. The right ear lymphedema model was created by surgical procedure; then, rabbits were divided into three randomized groups. Single and multiple venipuncture procedures were applied at least the 60th day after surgery for Group I and II, respectively. Group III was a control group. C-reactive protein (CRP) and procalcitonin (PCT) levels were analyzed to determine inflammation and infection. Ear thickness measurements were applied using a vernier caliper to assess the differences in lymphedema between the ears. All rabbits were euthanized on the 90th day after surgery. Histopathological analysis was performed to evaluate lymphedema by measuring tissue thicknesses. Ear thickness measurements showed that ear lymphedema was developed and maintained with surgical operation in all groups (p < 0.05). There was no difference in the ear thickness measurements between and within-groups results (p > 0.05). CRP and PCT levels were below the lower detection levels in all groups. According to the differences of histopathological ear distances, there were significant differences within-groups for all groups (p < 0.05), and no differences were identified between groups (p > 0.05).Conclusion: This experimental study demonstrated that single or multiple sterile venipuncture procedures did not trigger infection or inflammation and did not exacerbate ear lymphedema in the rabbit ear lymphedema model.en_US
dc.identifier.doi10.1089/lrb.2021.0095
dc.identifier.issn1539-6851
dc.identifier.issn1557-8585
dc.identifier.pmid35687408en_US
dc.identifier.scopus2-s2.0-85148679002en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1089/lrb.2021.0095
dc.identifier.urihttps://hdl.handle.net/20.500.14034/694
dc.identifier.wosWOS:000810175900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.journalLymphatic Research And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrabbit ear lymphedemaen_US
dc.subjectvenipunctureen_US
dc.subjectinfectionen_US
dc.subjectinflammationen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectBreast-Canceren_US
dc.subjectBacterial-Infectionen_US
dc.subjectArm Lymphedemaen_US
dc.subjectProcalcitoninen_US
dc.subjectLymphangiogenesisen_US
dc.subjectMacrophagesen_US
dc.subjectClearanceen_US
dc.subjectTherapyen_US
dc.subjectRisken_US
dc.titleDoes venipuncture increase lymphedema by triggering inflammation or infection? An experimental rabbit ear lymphedema model studyen_US
dc.typeArticleen_US

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