Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19

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dc.authoridAltin, Zeynep/0000-0003-3682-1479
dc.authoridArslan İnce, Fatma Demet/0000-0003-0766-0303
dc.authoridIyilikci, Veli/0000-0003-1071-1263
dc.authoridArslan, Fatma Demet/0000-0003-0766-0303
dc.authorwosidTurken, Melda/HGD-8968-2022
dc.authorwosidAltin, Zeynep/AAA-1427-2021
dc.authorwosidIyilikci, Veli/HGU-9216-2022
dc.authorwosidArslan İnce, Fatma Demet/AAZ-5735-2021
dc.authorwosidColak, Ayfer Aydogdu/GQP-0855-2022
dc.authorwosidArslan, Fatma Demet/ABG-6885-2021
dc.contributor.authorColak, Ayfer
dc.contributor.authorOncel, Dilek
dc.contributor.authorAltin, Zeynep
dc.contributor.authorTurken, Melda
dc.contributor.authorArslan, Fatma Demet
dc.contributor.authorIyilikci, Veli
dc.contributor.authorYilmaz, Nisel
dc.date.accessioned2023-03-22T19:47:42Z
dc.date.available2023-03-22T19:47:42Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractIn the present study, the importance of laboratory parameters and CT findings in the early diagnosis of COVID-19 was investigated. To this end, 245 patients admitted between April 1st, and May 30th, 2020 with suspected COVID-19 were enrolled. The patients were divided into three groups according to chest CT findings and RT-PCR results. The non-COVID-19 group consisted of 71 patients with negative RT-PCR results and no chest CT findings. Ninety-five patients with positive RT-PCR results and negative chest CT findings were included in the COVID-19 group; 79 patients with positive RT-PCR results and chest CT findings consistent with COVID-19 manifestations were included in COVID-19 pneumonia group. Chest CT findings were positive in 45% of all COVID-19 patients. Patients with positive chest CT findings had mild (n=30), moderate (n=21) andor severe (n=28) lung involvement. In the COVID-19 group, CRP levels and the percentage of monocytes increased significantly. As disease progressed from mild to severe, CRP, LDH and ferritin levels gradually increased. In the ROC analysis, the area under the curve corresponding to the percentage value of monocytes (AUC=0.887) had a very good accuracy in predicting COVID-19 cases. The multinomial logistic regression analysis showed that CRP, LYM and % MONO were independent factors for COVID-19. Furthermore, the chest CT evaluation is a relevant tool in patients with clinical suspicion of COVID-19 pneumonia and negative RT-PCR results. In addition to decreased lymphocyte count, the increased percentage of monocytes may also guide the diagnosis.en_US
dc.identifier.doi10.1590/S1678-9946202264028
dc.identifier.issn0036-4665
dc.identifier.issn1678-9946
dc.identifier.pmid35384959en_US
dc.identifier.scopus2-s2.0-85127623209en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/S1678-9946202264028
dc.identifier.urihttps://hdl.handle.net/20.500.14034/827
dc.identifier.volume64en_US
dc.identifier.wosWOS:000787670300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInst Medicina Tropical Sao Pauloen_US
dc.relation.journalRevista Do Instituto De Medicina Tropical De Sao Pauloen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMonocyte percentageen_US
dc.subjectChest CTen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectRT-PCRen_US
dc.titleUsefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19en_US
dc.typeArticleen_US

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