Does COVID-19 infection alter serum biochemical and hematological biomarkers in deceased dementia patients?

dc.authoridAydemir, Duygu/0000-0002-6449-2708
dc.authoridUlusu, Nuray Nuriye/0000-0002-3173-1389
dc.authoridYUCEL, MUAMMER/0000-0002-1646-3953
dc.contributor.authorAydemir, Duygu
dc.contributor.authorYucel, Muammer
dc.contributor.authorKoseoglu, Mehmet
dc.contributor.authorUlusu, Nuriye Nuray
dc.date.accessioned2025-03-20T09:50:36Z
dc.date.available2025-03-20T09:50:36Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractObjectives The elderly population is categorized as a risk group for COVID-19 infection, and dementia is the primary cause of disability in elderly individuals and affects 70 % of the elderly population. In this study, we evaluated the blood and serum biomarkers of deceased dementia patients infected by COVID-19 compared to the survived dementia and non-dementia patients.Methods Laboratory biomarkers of 11 dementia patients infected by COVID-19 have been used for this study. The five patients' serum biochemistry and blood data were compared with the six patients who died because of COVID-19. Additionally, data from nine patients aged 85-96 infected with COVID-19 without dementia have been used to compare the difference between dementia and non-dementia individuals.Results D-dimer, C-reactive protein (CRP), glucose, blood urea nitrogen (BUN), alanine transaminase (ALT), aspartate aminotransferase (AST), troponin, procalcitonin, red cell distribution width (RDW), white blood cell (WBC), neutrophil (NEU) and %NEU levels significantly increased in the deceased dementia patients compared to the survived and non-dementia individuals. Calcium (Ca), hematocrit (HCT), red blood cells (RBC), lymphocyte (%LYM), monocyte %MONO, and basophil (%BASO) levels significantly decreased in the deceased dementia patients compared to the survived and non-dementia individuals infected by COVID-19.Conclusions Serum biochemistry and hematological biomarkers, including D-dimer, CRP, glucose, ALT, AST, BUN, troponin, procalcitonin, RDW, RBC, WBC, NEU, %NEU, Ca, HCT, %LYM, %MONO, and %BASO were significantly altered in deceased dementia patients infected by COVID-19 compared to the survived individuals.
dc.description.sponsorshipPresidency of Turkey, Head of Strategy and Budget
dc.description.sponsorshipThe authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Head of Strategy and Budget.
dc.identifier.doi10.1515/tjb-2022-0206
dc.identifier.endpage367
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85203004150
dc.identifier.scopusqualityQ3
dc.identifier.startpage358
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0206
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2272
dc.identifier.volume49
dc.identifier.wosWOS:001224897400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectCOVID-19
dc.subjectdementia
dc.subjecthematological biomarkers
dc.subjectserum biochemistry parameters
dc.titleDoes COVID-19 infection alter serum biochemical and hematological biomarkers in deceased dementia patients?
dc.typeArticle

Dosyalar