Investigation of serum angiotensin-converting enzyme (ACE) concentration and ACE gene polymorphism in patients with SARS-CoV-2 pneumonia admitted to the emergency department

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dc.authoridKöseler, Aylin/0000-0003-4832-0436
dc.authorwosidKöseler, Aylin/C-5030-2012
dc.contributor.authorGoren, Tarik
dc.contributor.authorYilmaz, Atakan
dc.contributor.authorUluturk, Mehmet
dc.contributor.authorSabırlı, Ramazan
dc.contributor.authorKemanci, Aykut
dc.contributor.authorSeyit, Murat
dc.contributor.authorOzen, Mert
dc.date.accessioned2023-03-22T19:47:30Z
dc.date.available2023-03-22T19:47:30Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBackground This study seeks to investigate the distribution of the angiotensin-converting enzyme (ACE) gene polymorphism and serum levels in patients with viral pneumonia and predict which polymorphism will lead to severe progression of the disease. Methodology The serum ACE levels and ACE gene polymorphisms were successfully evaluated with respect to subsequent viral pneumonia using records of 100 patients with viral pneumonia and 100 healthy controls. Results ACE serum concentration was statistically significantly elevated. ACE serum concentration with a cut-off value of >= 5,256.05 pg/mL had 85.3% sensitivity and 83.2% selectivity. In addition, patients with ACE genotype D/D were 0.08 times more likely to manifest severe lung involvement than those with I/I, and patients with the I/D genotype were 0.02 times more likely than their counterparts with I/I. The computed tomography findings of the patients revealed that ACE serum concentration was significantly effective in discriminating between mild and moderate-to-severe lung involvement. No significant difference was observed between the blood parameters and ACE genotype distributions. Conclusions I/D polymorphism likely affects the expression of the ACE gene and/or the function of the angiotensin I converting enzyme. The D/D genotype is associated with vessel wall thickness and higher blood pressure. Strong evidence was found between D/D and I/D genotypes in the patient cohort concerning genotypes and ACE serum concentration. Further analysis showed that ACE serum levels were more elevated in the D/D genotype compared to the I/D genotype in the patient cohort.en_US
dc.identifier.doi10.7759/cureus.31201
dc.identifier.issn2168-8184
dc.identifier.issue11en_US
dc.identifier.pmid36505135en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.31201
dc.identifier.urihttps://hdl.handle.net/20.500.14034/735
dc.identifier.volume14en_US
dc.identifier.wosWOS:000908754300023en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.journalCureus Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsars-cov-2en_US
dc.subjectpneumoniaen_US
dc.subjectemergency departmenten_US
dc.subjectace serum levelsen_US
dc.subjectace polymorphismen_US
dc.subjectDeletion Polymorphismen_US
dc.subjectBlood-Pressureen_US
dc.subjectProgressionen_US
dc.subjectSeverityen_US
dc.titleInvestigation of serum angiotensin-converting enzyme (ACE) concentration and ACE gene polymorphism in patients with SARS-CoV-2 pneumonia admitted to the emergency departmenten_US
dc.typeArticleen_US

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