Histopathological and biomechanical investigation of the effect of momordica charantia on fracture healing, kidney, and liver: an experimental rat model

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dc.authorscopusid57222578003
dc.authorscopusid35111099800
dc.authorscopusid55241808800
dc.authorscopusid57204285426
dc.authorscopusid55924307300
dc.authorscopusid55899218700
dc.authorscopusid57209076063
dc.authorwosidinal, sermet/ABA-3899-2021
dc.contributor.authorÖzturk, Burhan
dc.contributor.authorİnal, Sermet
dc.contributor.authorDülgeroğlu, Turan Cihan
dc.contributor.authorÜzümcügil, Alaaddin Oktar
dc.contributor.authorDeger, Ayşenur
dc.contributor.authorKuyubasi, Sabit Numan
dc.contributor.authorGök, Kadir
dc.date.accessioned2022-02-15T16:58:20Z
dc.date.available2022-02-15T16:58:20Z
dc.date.issued2021
dc.departmentBakırçay Üniversitesien_US
dc.description.abstractMomordica charantia (MC) is a plant belonging to the family Cucurbitaceae. MC has antidiabetic, antibacterial, antioxidant, antimutagenic, antiulcerative, antiinflammatory and antilipidemic effects. However, information on the effect of MC on fracture union is lacking. This study aimed to examine the effect of MC on fracture union histopathologically and biomechanically. A total of 42 male Wistar-Albino rats were randomly divided into 3 groups, 14 in each group. A diaphyseal fracture was created on the right tibia of all rats. All fractures were fixed with a Kirschner (K) wire. The rats in Group I did not undergo any further procedures (Control group). Group II rats were treated with 0.9% saline oral gavage at a dose of 500 mu L/day for 28 days [Saline (S) group]. The rats in Group III were given 300mg/kg MC extract per day, dissolved in 500 mu L 0.9% saline by oral gavage for 28 days [MC (Extract) group]. After 28 days, all rats were sacrificed. Each group was randomly divided into two subgroups. The histopathological examination was performed on the right tibia of rats in the first subgroup and the biomechanical examination in the second subgroup. The kidneys and livers of all rats were evaluated histopathologically. Fracture union was significantly better in the Extract group compared with the Control and S groups histopathologically. The fracture inflammation values were lower in the Extract group than in the other groups. No statistically significant difference was found between the groups in terms of possible side effects to kidneys and livers. In terms of biomechanics, fracture union was significantly better in the Extract group compared with the Control and S groups except yield displacement values. MC had a positive effect on fracture union histopathologically and biomechanically.en_US
dc.identifier.doi10.1142/S0219519421500196
dc.identifier.issn0219-5194
dc.identifier.issn1793-6810
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85103277282en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1142/S0219519421500196
dc.identifier.urihttps://hdl.handle.net/20.500.14034/387
dc.identifier.volume21en_US
dc.identifier.wosWOS:000645136900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWorld Scientific Publ Co Pte Ltden_US
dc.relation.journalJournal Of Mechanics In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFracture healingen_US
dc.subjectkidneyen_US
dc.subjectliveren_US
dc.subjectMomordica charantiaen_US
dc.subjectraten_US
dc.subjectCortical Boneen_US
dc.subjectBitter Gourden_US
dc.subjectEstrogenen_US
dc.subjectExtracten_US
dc.subjectFatigueen_US
dc.subjectSodiumen_US
dc.subjectRepairen_US
dc.subjectMelonen_US
dc.titleHistopathological and biomechanical investigation of the effect of momordica charantia on fracture healing, kidney, and liver: an experimental rat modelen_US
dc.typeArticleen_US

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