A meta-analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells

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dc.contributor.authorKonuk, Elcin Yenidunya
dc.date.accessioned2025-03-20T09:50:29Z
dc.date.available2025-03-20T09:50:29Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractThe present study summarizes the current available literature regarding the viability of MCF7 breast cancer cells treated with gold (Au), silver (Ag) or zinc oxide (ZnO) nanoparticles at varying doses for 48 h. The data for this study were obtained from diverse research articles published between 2013 and 2023 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The evaluation focused on 20 PRISMA-compliant articles concerning MCF7 cells, yielding 137 outcome measures for meta-analysis. A generalized linear mixed model meta-analysis approach was employed to glean insights into the effects of novel nanoparticles on MCF7 breast cancer cells. The analysis covered a wide range of concentrations: Ag nanoparticles from 1.25 to 1,000 mu g/ml, Au nanoparticles from 50 to 150 mu g/ml, and ZnO nanoparticles from 1 to 1,000 mu g/ml. Both intra-nanoparticle and inter-nanoparticle comparisons were conducted to detect differences. The findings showed that when concentrations reached or exceeded 60 mu g/ml, considerable variation of cell viability was observed: Treatment with Ag nanoparticles resulted in cell viability ranging from 9 to 45%, ZnO nanoparticles resulted in cell viability ranging from 20 to 40%, and Au nanoparticles resulted in cell viability ranging from 3 to 58%. These findings indicated the significance of thoroughly exploring nanoparticle dosage to acquire a comprehensive understanding of their influence on cell viability.
dc.identifier.doi10.3892/ol.2024.14684
dc.identifier.issn1792-1074
dc.identifier.issn1792-1082
dc.identifier.issue5
dc.identifier.pmid39328279
dc.identifier.scopus2-s2.0-85204287770
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3892/ol.2024.14684
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2221
dc.identifier.volume28
dc.identifier.wosWOS:001320044900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKonuk, Elcin Yenidunya
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofOncology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectmeta-analysis
dc.subjectMCF7 cell line
dc.subjectnanoparticle
dc.subjectanticancer
dc.subjectcytotoxicity
dc.titleA meta-analysis assessing the cytotoxicity of nanoparticles on MCF7 breast cancer cells
dc.typeArticle

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