Anticancer activity of linalool: comparative investigation of ultrastructural changes and apoptosis in breast cancer cells

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dc.authoridYigitturk, Gurkan/0000-0002-5315-253X
dc.contributor.authorElbe, Hülya
dc.contributor.authorÖztürk, Feral
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorBaygar, Tuba
dc.contributor.authorÇavuşoğlu, Türker
dc.date.accessioned2023-03-22T19:47:21Z
dc.date.available2023-03-22T19:47:21Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractBreast cancer is the most common cancer in women in the world. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Linalool is aromatic compounds from the monoterpene group. It is the main constituents of essential oils and show antiproliferative, antioxidant, and antiseptic properties. The aim of this study was to investigate the antiproliferativeand apoptotic, effects of linalool in MCF-7 and MDA-MB-231 human breast cancer cells. MCF-7 and MDA-MB-231 human breast cancer cells were treated with different concentrations of linalool (100, 200, 400, 600, 800, 1000 mu M) at 24 h and 48 h. MTT assay for cell proliferation and Annexin V assay for apoptosis was done. The morphology of breast cancer cells was investigated by light microscope and scanning electron microscope (SEM). The study show that linalool significantly induced apoptosis in all groups as dose and time-dependent (p < .05). Linalool has apoptotic and antiproliferative properties in a concentration and time-dependent manner in breast cancer cells. The cytotoxic effects of linalool on MCF-7 and MDA-MB-231 human breast cancer cells was found to be associated with apoptotic cell death. Linalool was more effective on MCF-7 human breast cancer cells in smaller amounts.en_US
dc.description.sponsorshipScientific Research Fund of Mugla Sitki Kocman University [17/061]en_US
dc.description.sponsorshipThis study was financially supported by a grant from Scientific Research Fund of Mugla Sitki Kocman University (Grant number: 17/061).en_US
dc.identifier.doi10.1080/01913123.2022.2091068
dc.identifier.endpage358en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue4en_US
dc.identifier.pmid35727696en_US
dc.identifier.scopus2-s2.0-85132707072en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2022.2091068
dc.identifier.urihttps://hdl.handle.net/20.500.14034/644
dc.identifier.volume46en_US
dc.identifier.wosWOS:000814171400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.journalUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectanticanceren_US
dc.subjectbreast canceren_US
dc.subjectlinaloolen_US
dc.subjectultrastructureen_US
dc.subjectProstate-Canceren_US
dc.subjectLineen_US
dc.subjectNanoparticlesen_US
dc.titleAnticancer activity of linalool: comparative investigation of ultrastructural changes and apoptosis in breast cancer cellsen_US
dc.typeArticleen_US

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