CAN BE A PREFERABILITY BETWEEN INDUCTION ANESTHETIC AGENTS FOR FRACTURE SURGERY. HISTOPATHOLOGICAL AND BIOMECHANICAL APPROACH ON RATS

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dc.contributor.authorKuyubasi, Sabit Numan
dc.contributor.authorInal, Canan
dc.contributor.authorInal, Sermet
dc.contributor.authorInal, Mehmet Turan
dc.contributor.authorDeger, Aysenur
dc.contributor.authorGok, Kadir
dc.contributor.authorOner, Suleyman Kaan
dc.date.accessioned2023-03-22T19:47:22Z
dc.date.available2023-03-22T19:47:22Z
dc.date.issued2023
dc.departmentBelirleneceken_US
dc.description.abstractAs the effect of many medical agents such as nonsteroidal anti-inflammatory drugs or antibiotics were investigated on bone fracture healing, there is no study about the anesthetic agents when compared histopathologically and biomechanically. We asked the question that if a superiority can be between them since we operate many fractures and see the delayed or nonunions. Although different anesthetic agents are used in general anesthesia, the effects of these substances on bone fracture healing are not clear. Here, we intended to research different anesthetic agents on fracture union in rats. The study was done between January 2020 and November 2021 in a university animal research laboratory. Totally 48 male Wistar-Albino rats weighing 250-300g were seperated into 3 groups as Tiyopental Na in Group 1, Ketamin in Group 2 and Propofol in Group 3. For anesthesia; 40, 100, 100mg/kg of single dosages were injected intraperitoneally, respectively. A shaft fracture was created bilaterally to the tibia of all rats. Kirschner (K) wire is used for the fixation of fractures. Biomechanical and histopathological examination in bones is performed at the end of the first and second months in terms of fracture healing. It has been found that the fracture union in group 1 was statistically signifigant higher than group 3 at the end of the first and second months histopathologically (P = 0.006, P = 0.002). It is also found there is a statistically significant difference between groups 1 and 3 after the second month biomechanically (P = 0.013). Although the union was higher in group 1 than group 2 histopathologically and biomechanically after the first and second months, there was no statistically significant difference (P = 0.376, 0.039; P = 0.028, 0.867). There was a general trend in the decrease of union measurements starting from group 1 to 3 at the end of the first and second month both histopathologically and biomechanically. In this study, it is found that there was a positive consistency between histopathological and biomechanical results with respect to bone union. They supported each other. Fracture healing is stronger in rats that were anesthetized by using thiopental than those using ketamine and propofol, we think that this may affect the choice of anesthetic agent and further studies are needed.en_US
dc.identifier.doi10.1142/S0219519423500185
dc.identifier.issn0219-5194
dc.identifier.issn1793-6810
dc.identifier.scopus2-s2.0-85147170957en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1142/S0219519423500185
dc.identifier.urihttps://hdl.handle.net/20.500.14034/655
dc.identifier.wosWOS:000923084800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWorld Scientific Publ Co Pte Ltden_US
dc.relation.journalJournal Of Mechanics In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiopentalen_US
dc.subjectketamineen_US
dc.subjectpropofolen_US
dc.subjectfracture healingen_US
dc.subjectbiomechanicsen_US
dc.subjectNonsteroidal Antiinflammatory Drugsen_US
dc.subjectPharmacological Agentsen_US
dc.subjectPropofolen_US
dc.subjectBoneen_US
dc.subjectDiclofenacen_US
dc.subjectKetamineen_US
dc.subjectProstaglandinsen_US
dc.subjectInhibitionen_US
dc.subjectImpacten_US
dc.subjectActivationen_US
dc.titleCAN BE A PREFERABILITY BETWEEN INDUCTION ANESTHETIC AGENTS FOR FRACTURE SURGERY. HISTOPATHOLOGICAL AND BIOMECHANICAL APPROACH ON RATSen_US
dc.typeArticleen_US

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