Inquiries of DNA Interaction of Cobalt (II) Phthalocyanine Compound Bearing 4-tritylphenoxy Groups

Basit Öğe Kaydı
dc.contributor.authorArslantas, Ali
dc.contributor.authorAgirtas, Mehmet Salih
dc.date.accessioned2025-03-20T09:50:27Z
dc.date.available2025-03-20T09:50:27Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstract[Tetrakis-(4-tritylphenoxy) phthalocyaninato] Cobalt (II) (PcCo) was previously formed via the reaction of 4-(4-tritylphenoxy)phthalonitrile. The structure of the resulting PcCo was characterized using absorption spectra, infrared and NMR spectroscopies. The deoxyribonucleic acid (DNA) connecting feature for PcCo was inquired in the different concentration of Calf Thymus- deoxyribonucleic acid (CT-DNA) using UV/Vis, fluorescence spectroscopy, gel agarose electrophoresis and thermal denaturation methods. UV/Vis spectrometer and fluorescence spectroscopy verified PcCo bounds to the DNA and the binding constant (Kb) b ) of the PcCo was also calculated. The binding constant Kb b is a very important parameter for getting information on the binding mechanism. The Kb b of the compound was also calculated as 1.44 x 106 6 M-1.-1 . The value of Kb b demonstrated that the complex binds to DNA through an intercalative binding mechanism. Additionally, thermal denaturation and the electrophoresis studies were implemented to analyze the interacting of PcCo via CT-DNA. In the absence of the complex, the melting experiments were conducted for CT-DNA and Tm m was found 69.6 o C for the DNA and The Tm m of PcCo complex was found 76.3 o C. Melting point temperature and electrophoresis experiments demonstrated that PcCo binds to CT-DNA through intercalation binding mechanisms. The acquired findings confirmed that PcCo links to the DNA via the intercalating binding manner. Therefore, PcCo may have potential use in cancer treatment. Because of this, further research is needed before this complex can be used in cancer treatment.
dc.description.sponsorshipKarabuk University [KBBAP-18-DS-046]; [KBUEBAP-18-DS-046]
dc.description.sponsorshipThis research was supported by Karabuk University. Project No: KBUBAP-18-DS-046.
dc.identifier.doi10.52568/001550/JCSP/46.05.2024
dc.identifier.endpage507
dc.identifier.issn0253-5106
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85207427152
dc.identifier.scopusqualityQ3
dc.identifier.startpage499
dc.identifier.urihttps://doi.org/10.52568/001550/JCSP/46.05.2024
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2194
dc.identifier.volume46
dc.identifier.wosWOS:001339487900010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherChem Soc Pakistan
dc.relation.ispartofJournal of The Chemical Society of Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectDNA
dc.subjectPhthalocyanine
dc.subjectBinding Mode
dc.subjectAbsorption spectra
dc.subjectFluorescence spectroscopy
dc.titleInquiries of DNA Interaction of Cobalt (II) Phthalocyanine Compound Bearing 4-tritylphenoxy Groups
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Tam Metin / Full Text
Boyut:
931.93 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu