The Relationship Between Premature Adrenarche and Markers of Inflammation in Complete Blood Count

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dc.authoridEvin, Ferda/0000-0001-7169-890X
dc.authoridErtekin, Mehtap/0000-0003-1622-890X
dc.contributor.authorEvin, Ferda
dc.contributor.authorAyranci, Ilkay
dc.contributor.authorErtekin, Mehtap
dc.date.accessioned2025-03-20T09:50:28Z
dc.date.available2025-03-20T09:50:28Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractAim: Premature adrenarche (PA) has been associated with metabolic and polycystic ovary syndrome (PCOS) and, thus, with an increased risk for type 2 diabetes and cardiovascular diseases in later life. Mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), and platelet/ lymphocyte ratio (PLR) are parameters used to show inflammation. This study planned to evaluate systemic inflammation in children with PA using MPV, NLR, and PLR. Materials and Methods: The study included 40 female patients diagnosed with PA and 40 healthy female individuals as a control group. The patient and control groups' MPV, NLR, and PLR values were compared. Results: The mean age of the PA group was 7.18 +/- 0.66 years, and the mean age of the control group was 7.09 +/- 1.08 years. The mean MPV and platelet distribution width (PDW) values in the PA group were significantly higher than those in the control group (10.25 +/- 0.87 vs 9.52 +/- 0.79, p<0.001 and 15.43 +/- 1.31 vs 14.35 +/- 1.84, p=0.04, respectively). However, in the PA group, NLR and PLR were not significantly different from the values in the control group (p>0.05). The results of multivariate logistic regression analysis revealed that the MPV [odds ratio (OR); 95% confidence interval (CI): 0.331 (0.174-0.630); p=0.001], and PDW [OR; 95%: CI: 0.612 (0.425-0.884); p=0.008] were associated with PA in the patient group. Conclusion: Our results demonstrated that PA patients had significantly higher MPV levels and PDW than the healthy controls. Hence, recognition of early markers in adolescence might reveal primary pathogenetic alterations predictive of the later development of PCOS and/or metabolic syndrome.
dc.identifier.doi10.4274/jpr.galenos.2024.13911
dc.identifier.endpage57
dc.identifier.issn2147-9445
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85208451015
dc.identifier.scopusqualityN/A
dc.identifier.startpage52
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2024.13911
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2206
dc.identifier.volume11
dc.identifier.wosWOS:001193683900008
dc.identifier.wosquality#YOK
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofJournal of Pediatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectPremature adrenarche
dc.subjectmean platelet volume
dc.subjectneutrophil/lymphocyte ratio
dc.subjectplatelet/lymphocyte ratio
dc.subjectcardiovascular diseases
dc.subjectinflammation
dc.titleThe Relationship Between Premature Adrenarche and Markers of Inflammation in Complete Blood Count
dc.typeArticle

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