Demonstration of the protective effect of propofol in rat model of cisplatin-induced neuropathy

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dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.contributor.authorGonullu, Edip
dc.contributor.authorDagistan, Gozde
dc.contributor.authorErkin, Yuksel
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-03-09T18:48:48Z
dc.date.available2024-03-09T18:48:48Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractCisplatin is commonly used in the treatment of lung, genitourinary, and gastrointestinal cancers. Peripheral neuropathy is the most important side effect, leading to a decrease in the dose of cisplatin or its complete cessation in the early period. 16 rats were given cisplatin at a dose of 2.5 mg/ kg/day twice a week for 4 weeks to induce neuropathy model. The rats taking Cisplatin were divided into 2 groups. Group 1 rats (n = 8) were given 1 ml/kg/day 0.9 % NaCl intraperitoneally, and Group 2 rats were given 10 mg/kg/day Propofol intraperitoneally daily for 4 weeks. The remaining 8 rats served as the control group. At the end of the study, all animals were tested for motor functions. Blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF-alpha), glutathione (GSH), IL-6 and HSP-70 levels. Electromyography findings revealed that compound muscle action potential (CMAP) amplitude was significantly higher in the cisplatin-Propofol group than in the cisplatin-saline group. Also, cisplatin-Propofol treated group showed significantly lower TNF-alpha, MDA and IL-6 levels and higher GSH and HSP-70 levels than cispalatin-Saline group (p < 0.01, p < 0.001). In addition, while the CMAP latency was decreased in the propofol group, the CMAP amplitude was increased, and a significant improvement was observed in the Inclined test scores. Besides, histological examinations showed an increase in axon diameter and NGF expression with Propofol treatment. This study demonstrated that Propofol exerts protective activity against cisplatin-induced neurotoxicity by increasing endogenous antioxidants and reducing lipid peroxidation and inflammation (Tab. 3, Fig. 4, Ref. 30). Text in PDF www.elis.sken_US
dc.identifier.doi10.4149/BLL_2023_010
dc.identifier.endpage69en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1en_US
dc.identifier.pmid36519610en_US
dc.identifier.scopus2-s2.0-85144586065en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2023_010
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1486
dc.identifier.volume124en_US
dc.identifier.wosWOS:001092683600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatin; Neuropathy; Propofol; Oxidative Damage; Inflammationen_US
dc.titleDemonstration of the protective effect of propofol in rat model of cisplatin-induced neuropathyen_US
dc.typeArticleen_US

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