Evaluation of primary and accessory respiratory muscles and their influence on exercise capacity and dyspnea in pulmonary arterial hypertension

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dc.authoridzeren, Melih/0000-0002-9749-315X
dc.authorwosidzeren, Melih/HNR-7817-2023
dc.contributor.authorDurdu, Habibe
dc.contributor.authorDemir, Rengin
dc.contributor.authorZeren, Melih
dc.contributor.authorBasturk, Pinar
dc.contributor.authorArabaci, Hidayet Ozan
dc.contributor.authorSinan, Umit Yasar
dc.contributor.authorKucukoglu, Mehmet Serdar
dc.date.accessioned2023-03-22T19:47:27Z
dc.date.available2023-03-22T19:47:27Z
dc.date.issued2023
dc.departmentBelirleneceken_US
dc.description.abstractBackground: Skeletal and respiratory muscle disfunction has been described in pulmonary arterial hypertension (PAH), however, involvement of accessory respiratory muscles and their association with symptomatology in PAH is unclear. Objectives: To assess the primary and accessory respiratory muscles and their influence on exercise tolerance and dyspnea. Methods: 27 patients and 27 healthy controls were included. Serratus anterior (SA), pectoralis muscles (PM) and sternocleidomastoid (SCM) muscle strength were evaluated as accessory respiratory muscles, maximal inspiratory (MIP) and expiratory pressures (MEP) as primary respiratory muscles, and quadriceps as peripheral muscle. Exercise capacity was evaluated with 6-min walk test (6MWT), dyspnea with modified Medical Council Research (MMRC) and London Chest Activity of Daily Living (LCADL) scales. Results: All evaluated muscles, except SCM, and 6MWT were decreased in patient group (p < 0.01). SA was the most affected muscle among primary and accessory respiratory muscles (Cohen's-d = 1.35). All evaluated muscles significantly correlated to 6MWT (r = 0.428-0.525). A multivariate model including SA, SCM and MIP was the best model for predicting 6MWT (R = 0.606; R-2 = 0.368; p = 0.013) and SA strength had the most impact on the 6MWT (B =1.242; beta = 0.340). None of the models including respiratory muscles were able to predict dyspnea, however PM and SA strength correlated to LCADL(total) (r =-0.493) and MMRC (r =-0.523), respectively. Conclusion: SCM may be excessively used in PAH since it retains its strength. Considering the relationship of accessory respiratory muscles with exercise tolerance and dyspnea, monitoring the strength of these muscles in the clinical practice may help providing better management for PAH. (C) 2022 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.hrtlng.2022.09.015
dc.identifier.endpage179en_US
dc.identifier.issn0147-9563
dc.identifier.issn1527-3288
dc.identifier.pmid36219922en_US
dc.identifier.scopus2-s2.0-85139639262en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1016/j.hrtlng.2022.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.14034/709
dc.identifier.volume57en_US
dc.identifier.wosWOS:000869724800005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.journalHeart & Lungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAccessory respiratory muscleen_US
dc.subjectDyspneaen_US
dc.subjectExercise capacityen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectRespiratory muscleen_US
dc.subjectSkeletal muscle strengthen_US
dc.subjectPhysical-Activityen_US
dc.subjectStrengthen_US
dc.subjectArmen_US
dc.subjectLimben_US
dc.titleEvaluation of primary and accessory respiratory muscles and their influence on exercise capacity and dyspnea in pulmonary arterial hypertensionen_US
dc.typeArticleen_US

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