Hyperandrogenism correlates with psychological symptoms in adolescents with polycystic ovary syndrome
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Jeff Corporation Co. Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to analyze the depressive and anxiety states of adolescent girls with polycystic ovary syndrome (PCOS). This was a cross-sectional, multicenter, case–control study. A total of 100 participants (PCOS group, 51; control group, 49) aged 13–18 yr were included in the study. Body mass index was higher in patients with PCOS (P = 0.002). In the PCOS group, 28.5% of the patients had moderate-to-severe depressive symptoms, whereas the incidence was lower in controls (8.3%, P = 0.021). The State-Trait Anxiety Inventory (STAI)-State, STAI-Trait, and physical, psychosocial, and total Pediatric Quality of Life Inventory PedsQL scores were higher in the PCOS group, suggesting that anxiety was more common and the quality of life was worse in patients with PCOS than in healthy participants (P = 0.01, P = 0.03, P = 0.02, P = 0.046, and P = 0.047, respectively). The serum free testosterone (fT) levels were positively correlated with the depression and anxiety scores and negatively correlated with the psychosocial PedsQL scores. In conclusion, adolescent girls diagnosed with PCOS demonstrated higher depressive and anxiety symptoms and lower psychosocial quality of life scores than their healthy counterparts. A relationship was found between the fT level and all psychological measures. © 2022 by The Japanese Society for Pediatric Endocrinology.
Açıklama
Anahtar Kelimeler
adolescent, depression, hyperandrogenism, Polycystic ovary syndrome, psychological well-being, alanine aminotransferase, androstenedione, aspartate aminotransferase, estradiol, follitropin, hydroxyprogesterone, luteinizing hormone, prasterone sulfate, prolactin, testosterone, thyrotropin, acanthosis, acanthosis nigricans, acne, adolescent, adult, anxiety, Article, Beck Depression Inventory, body fat percentage, body height, body mass, body weight, case control study, chemiluminescence immunoassay, controlled study, cross-sectional study, depression, echography, enzyme assay, female, glucose blood level, health service, hexokinase assay, hirsutism, homeostasis model assessment, human, hyperandrogenism, insulin blood level, major clinical study, menstrual cycle, menstruation, mental disease, multicenter study, non insulin dependent diabetes mellitus, obesity, oligomenorrhea, oral glucose tolerance test, ovary polycystic disease, Pediatric Quality of Life Inventory, psychological well-being, quality of life, questionnaire, radioimmunoassay, spectrophotometry, State Trait Anxiety Inventory, testosterone blood level, vaccination
