Aesculus hippocastanum Alleviates Diabetic Neuropathy by Reducing MMP-9 and MMP-10 Levels

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dc.authoridErdogan, Mumin/0000-0003-0048-444X
dc.contributor.authorGonullu, Edip
dc.contributor.authorDagistan, Gozde
dc.contributor.authorOzsezer, Yakup
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorErbas, Oytun
dc.date.accessioned2025-03-20T09:50:29Z
dc.date.available2025-03-20T09:50:29Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground and Objective: Diabetic neuropathy (DN) is a prevalent complication of diabetes, characterized by neuropathic pain and motor dysfunction. The role of oxidative stress and inflammation in DN pathophysiology is well-documented. This study aims to evaluate the therapeutic potential of Aesculus hippocastanum (AH) in mitigating DN symptoms, focusing on its antioxidant and anti-inflammatory properties. Materials and Methods: The study utilized 40 adult male Wistar rats, divided into four groups: Control, diabetic and two AH-treated groups (receiving 10 mg kgG1 and 20 mg kgG1 AH, respectively). Diabetes was induced using streptozotocin (STZ) injections. Evaluations included lipid peroxidation (via malondialdehyde levels), matrix metalloproteinases (MMP-9 and MMP-10) levels, electrophysiological records (assessing compound muscle action potential), histopathological examination of the sciatic nerve and motor function tests (using an inclined plane). Results: The AH-treated groups exhibited a significant reduction in MDA levels, indicating decreased lipid peroxidation. Plasma MMP-9 and MMP-10 levels were also lower in these groups, suggesting reduced inflammation. Electrophysiological records showed increased CMAP amplitudes and decreased distal latency in AH-treated rats, indicative of improved nerve conduction. Histopathological examination revealed reduced perineural thickness in the sciatic nerve of AH-treated rats, suggesting less fibrosis. In motor function tests, AH-treated rats demonstrated enhanced performance, implying improved muscle strength and motor capacity. Conclusion: The findings indicate that AH treatment effectively reduces oxidative stress and inflammation in a rat model of diabetic neuropathy, leading to improved neuropathic symptoms. These results suggest that AH could be a promising therapeutic agent for managing DN, warranting further investigation for its potential clinical application.
dc.identifier.doi10.3923/ijp.2023.862.871
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue7
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.3923/ijp.2023.862.871
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2219
dc.identifier.volume19
dc.identifier.wosWOS:001178136500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherAsian Network Scientific Information-Ansinet
dc.relation.ispartofInternational Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectDiabetic neuropathy
dc.subjectAesculus hippocastanum
dc.subjectMMP-9 and MMP-10
dc.subjectoxidative stress
dc.subjectanti-inflammatory treatment
dc.subjectneuropathy management
dc.titleAesculus hippocastanum Alleviates Diabetic Neuropathy by Reducing MMP-9 and MMP-10 Levels
dc.typeArticle

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