Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats

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dc.authoridokur, mehmet evren/0000-0001-7706-6452
dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authoridKolbasi, Bircan/0000-0001-7933-4262
dc.authoridParlar Koprulu, Rabia Edibe/0000-0003-0052-3648
dc.authorwosidokur, mehmet evren/AAI-1962-2019
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.contributor.authorKoprulu, Rabia Edibe Parlar
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorKolbasi, Bircan
dc.contributor.authorKeskin, Ilknur
dc.contributor.authorOzbek, Hanefi
dc.date.accessioned2024-03-09T18:48:52Z
dc.date.available2024-03-09T18:48:52Z
dc.date.issued2022
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackground: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects.Objectives: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis.Methods: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen's score.Results: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg Conclusions: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.en_US
dc.identifier.doi10.5812/ijpr-132265
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.issue1en_US
dc.identifier.pmid36942057en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.5812/ijpr-132265
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1515
dc.identifier.volume21en_US
dc.identifier.wosWOS:001016337500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrieflanden_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTestis; Testosterone; Spermatogenesis; Rat; Diabetes Mellitusen_US
dc.titleEffects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Ratsen_US
dc.typeArticleen_US

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