HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds

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dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authoridKirmizi Sonmez, N Ipek/0000-0002-8593-0818
dc.authoridBardakci, Hilal/0000-0001-8799-6565
dc.authoridBarak, Timur Hakan/0000-0002-7434-3175
dc.authoridSAKUL, AYSE ARZU/0000-0002-9354-0000
dc.authoridKirmizi Sonmez, N. Ipek/0000-0001-8294-0802
dc.authorwosidSayin Sakul, AYSE Arzu/HOH-9547-2023
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.authorwosidBardakci, Hilal/AAH-9377-2019
dc.authorwosidKirmizi Sonmez, N Ipek/HDM-7962-2022
dc.authorwosidBarak, Timur Hakan/AAC-2862-2019
dc.contributor.authorSonmez, Neriman Ipek Kirmizi
dc.contributor.authorAcıkara, Özlem Bahadır
dc.contributor.authorSakul, Ayse Arzu
dc.contributor.authorBahtiyar, Bade Cevriye
dc.contributor.authorBardakci, Hilal
dc.contributor.authorBarak, Timur Hakan
dc.contributor.authorOzbek, Hanefi
dc.date.accessioned2023-03-22T19:47:28Z
dc.date.available2023-03-22T19:47:28Z
dc.date.issued2022
dc.departmentBelirleneceken_US
dc.description.abstractScorzonera L. (Asteraceae) species have long been the topic of many phytochemical, analytical, and biological studies since various species of the Scorzonera genus have been widely used as food and medicinal purposes. Apart from its traditional use to relieve pain, promote wound healing, treat helminth infections or women infertility, Scorzonera latifolia (Fisch. & Mey.) DC is also used for its antidiabetic activity. We aimed to investi-gate antidiabetic activity of the aerial parts of the title plant and its major secondary metabolites (hyperoside, isoquercitrin, 7-O-methylisoorientin, isoorientin, swertisin, chlorogenic acid, 4,5-O-dicaffeoylquinic acid and hydrangenol-8-O-b-glucoside) isolated from aerial parts in alloxan-induced diabetic mice. Blood glucose lev-els were measured four times: before the treatment, after 1st, 2nd, and 4th hours of sample treatments (100 mg/kg i.p.). S. latifolia extract displayed notable decline after 4 hours of administration. Among the metabolites; swertisin, 7-O-methyl-isoorientin, and hydrangenol-8-O-b-glucoside were associated with sig-nificant reduction on blood glucose level of alloxan-induced diabetic mice. Due to the strong relationship between oxidative stress and diabetes, antioxidant activity of S. latifolia was additionally tested. Furthermore, 4,5-O-dicaffeoylquinic acid, chlorogenic acid, hyperoside, and swertisin contents as major components of the extract were quantified by HPTLC-densitometry, as their biological effects can be attributed to their phenolic contents. (c) 2022 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.sajb.2022.07.041
dc.identifier.endpage677en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85136464821en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2022.07.041
dc.identifier.urihttps://hdl.handle.net/20.500.14034/725
dc.identifier.volume150en_US
dc.identifier.wosWOS:000859559700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalSouth African Journal Of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlloxanen_US
dc.subjectAntidiabetic activityen_US
dc.subjectScorzonera latifoliaen_US
dc.subjectHPTLCen_US
dc.subjectAntioxidanten_US
dc.subjectO -dicaffeoylquinic aciden_US
dc.subjectChlorogenic aciden_US
dc.subjectHyperosideen_US
dc.subjectSwertisinen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectMedicinal-Plantsen_US
dc.subjectChlorogenic Aciden_US
dc.subjectAntidiabetic Compoundsen_US
dc.subjectSecondary Metabolitesen_US
dc.subjectLeavesen_US
dc.subjectDivaricataen_US
dc.subjectHyperosideen_US
dc.subjectAerialen_US
dc.titleHPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compoundsen_US
dc.typeArticleen_US

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