Evaluation of D-dimer levels measured by different analytical methods in COVID-19 patients

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dc.authorid0000-0003-0766-0303en_US
dc.authorscopusid57190765494en_US
dc.contributor.authorArslan, Fatma Demet
dc.contributor.authorBaşok, Banu İşbilen
dc.contributor.authorTerzioğlu, Mustafa
dc.contributor.authorAltan, Tuba Kansu
dc.contributor.authorKaraca, Yeşer
dc.contributor.authorSenger, Süheyla Serin
dc.contributor.authorÇolak, Ayfer
dc.date.accessioned2022-04-01T09:19:35Z
dc.date.available2022-04-01T09:19:35Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractClinicians experience some challenges due to the lack of standardization of test, although D-dimer is a prognostic marker for COVID-19. We compared the clinical and analytical performances of D-dimer results obtained from different devices, kits and methods in patients with a diagnosis of COVID-19. Thirty-nine patients with a diagnosis of COVID-19 and 24 healthy individuals were included in the study. D-dimer levels were measured with Innovance D-DIMER kit (immunoturbidimetric method) on Sysmex CS-2500 and BCS XP and VIDAS D-Dimer Exclusion II kit (enzyme-linked fluorescence method) on mini VIDAS. The studies of precision, method comparison and clinic performance were performed. The variation coefficients in all systems were within the acceptable imprecision (7.8%). Bias%(12.5%) between BCS XP and Sysmex CS-2500 was lower than the acceptable Bias%(15.5%). Bias% values (19.2% and 33.3%, respectively) between Mini VIDAS with BCS XP and Sysmex CS-2500 were higher than the acceptable Bias%. The correlation coefficients among all systems were 0.89-0.98. For 500 ng/ml FEU, there was almost perfect agreement between BCS XP and Sysmex CS-2500, a moderate agreement between Mini VIDAS and BCS XP and Sysmex CS-2500. The cut-off values for distinguishing between individuals with and without COVID-19 were Mini VIDAS, Sysmex CS-2500 and BCS XP 529, 380 and 390 ng/ml FEU, respectively. The immunoturbidimetric method can be used as an alternative to the enzyme-linked fluorescent method because of satisfactory agreement at the different thresholds proposed for venous thromboembolism. However, it is recommended to follow up COVID-19 with the D-dimer results obtained by the same assay system.en_US
dc.identifier.citationArslan, F. D., Başok, B. İ., Terzioğlu, M., Altan, T. K., Karaca, Y., Senger, S. S., & Çolak, A. (2022). Evaluation of D-dimer levels measured by different analytical methods in COVID-19 patients. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 10.1097/MBC.0000000000001129. Advance online publication. https://doi.org/10.1097/MBC.0000000000001129en_US
dc.identifier.doi10.1097/MBC.0000000000001129
dc.identifier.issueOnline ahead of printen_US
dc.identifier.pmid35239616en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14034/526
dc.identifier.uridoi: 10.1097/MBC.0000000000001129
dc.identifier.volumeOnline ahead of printen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArslan, Fatma Demet
dc.language.isoenen_US
dc.relation.journalBlood Coagulation and Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectD-dimeren_US
dc.subjectEnzyme-linked fluorescent methoden_US
dc.subjectImmunoturbidimetryen_US
dc.subjectVenous thromboembolismen_US
dc.titleEvaluation of D-dimer levels measured by different analytical methods in COVID-19 patientsen_US
dc.typeArticleen_US

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