Biomechanical Effects of Angiotensin 1-7 in Diabetes Rats Femur

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dc.authoriddalaman, ugur/0000-0001-7145-4139
dc.contributor.authorNalbant, Asrın
dc.contributor.authorDalaman, Uğur
dc.contributor.authorGök, Kadir
dc.contributor.authorDuygu, Özden Bedre
dc.contributor.authorYaras, Nazmi
dc.contributor.authorKavak, Servet
dc.date.accessioned2024-03-09T18:48:57Z
dc.date.available2024-03-09T18:48:57Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractIt is known that diabetes mellitus has late complications, including microvascular and macrovascular diseases. Diabetes can affect bones through biochemical markers of bone structure, density, and turnover. This study aimed to biomechanically investigate the bone-protective effects of angiotensin 1-7 (Ang 1-7), one of the active peptides in the renin-angiotensin system, in rats with diabetes. Thirty male Wistar albino rats, three months old and weighing 250-300 g, were divided into four groups: diabetes, Ang 1- 7, diabetes plus Ang 1-7, and control. One month later, diabetes developed in rats; the rats were sacrificed, and their right femur was removed. Three-point bending biomechanical tests were performed on the femurs. The diabetic group had significantly higher bone fragility than the other groups (Pr >.05). Bone fragility was lower, and bone flexibility was higher in the Ang 1-7 groups (Pr>F value 0.05). As a result of our study, the effect of Ang 1-7 on the bones of rats with diabetes was investigated biomechanically. Ang 1-7 has a protective impact on the bones of rats with diabetes.en_US
dc.description.sponsorshipTUBITAK [117S066]en_US
dc.description.sponsorshipTUBITAK supported this study as a national program with project numbered 117S066.en_US
dc.identifier.endpage900en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage894en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1534
dc.identifier.volume41en_US
dc.identifier.wosWOS:001033597900031en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitus; Angiotensin 1-7; Three Point Bending Test; Bone; Renin-Angiotensin Systemen_US
dc.titleBiomechanical Effects of Angiotensin 1-7 in Diabetes Rats Femuren_US
dc.typeArticleen_US

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