Spectroscopic Evaluation of DNA Binding Activities of Copper (II) Phthalocyanine Complex Consisting of Tetrakis-(4-Tritylphenoxy) Ligand

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dc.contributor.authorArslantas, Ali
dc.contributor.authorAğırtaş, Mehmet Salih
dc.contributor.authorSolğun, Derya Güngördü
dc.date.accessioned2025-03-21T07:38:00Z
dc.date.available2025-03-21T07:38:00Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractThe structure and basic properties of Cu(II) phthalocyanine compound possessing tetrakis-(4-tritylphenoxy) group were elucidated in a past study with the help of absorption and infrared spectroscopic equipments. The electronic spectra, emission spectroscopy, gel agarose electrophoresis and thermal melting were employed to reveal the DNA interaction functions of this complex at changing concentrations of CT-DNA. In this experiment, the binding constant for the Cu(II) phthalocyanine compound which contains the tetrakis(4-tritylphenoxy) group was computed to be 1.53 x 106 M-1. The data obtained from absorption and fluorescence spectroscopic studies revealed that the CuPc compound reacted with CT-DNA through an intercalating mechanism. Well as the above methods, melting temperature and electrophoresis were also employed to analyse the interaction feature of CuPc with DNA. The interaction of the CuPc compound with DNA was also confirmed by data from melting temperature and electrophoresis experiments. Within the framework of the results obtained, it is predicted that CuPc compound may be a possible cancer therapeutic agent.
dc.description.sponsorshipGazi University
dc.identifier.doi10.35378/gujs.1588595
dc.identifier.doihttps://doi.org/10.35378/gujs.1588595
dc.identifier.issn2147-1762
dc.identifier.startpage1-Jan
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2635
dc.language.isoen
dc.publisherGazi Üniversitesi
dc.relation.ispartofGazi University Journal of Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250319
dc.subjectCopper (II)
dc.subjectDNA interaction
dc.subjectPhthalocyanines
dc.subjectAbsorption spectra
dc.subjectGel electrophoresis
dc.titleSpectroscopic Evaluation of DNA Binding Activities of Copper (II) Phthalocyanine Complex Consisting of Tetrakis-(4-Tritylphenoxy) Ligand
dc.typeArticle

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