Association between fetal fraction of cell-free DNA and adverse pregnancy outcomes

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dc.authoridEkin, Atalay/0000-0002-4712-3927
dc.authoridBayraktar, Burak/0000-0001-6233-4207
dc.authoridALKAN, KAAN OKAN/0000-0002-0029-2352
dc.authoridOzyilmaz, Berk/0000-0003-2654-3698
dc.authoridAdiyaman, Duygu/0000-0002-5307-8149
dc.authoridOzer kaya, Ozge/0000-0001-6731-2461
dc.authoridOzdemir, Taha Resid/0000-0003-4870-6945
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorBayraktar, Burak
dc.contributor.authorGolbasi, Ceren
dc.contributor.authorOmeroglu, Ibrahim
dc.contributor.authorAdiyaman, Duygu
dc.contributor.authorAlkan, Kaan Okan
dc.contributor.authorOzdemir, Taha Resid
dc.date.accessioned2025-03-20T09:51:20Z
dc.date.available2025-03-20T09:51:20Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractPurpose To determine the association between fetal fraction (FF) levels in cell-free fetal DNA (cffDNA) testing and adverse pregnancy outcomes. Methods This retrospective cohort study, conducted at a single center, involved 2063 pregnant women with normal 1st and 2nd trimester non-invasive prenatal test (NIPT) results between 2016 and 2021. Pregnancy outcomes were examined by determining the < 4% and < 5th percentile (3.6%) cut-off values for low fetal fraction (LFF). Pregnancy outcomes were also examined by dividing the FF into population-based quartiles. Adverse pregnancy outcomes were pregnancy-induced hypertensive diseases (PIHD), gestational diabetes mellitus (GDM), spontaneous preterm birth (PTB), intrahepatic cholestasis of pregnancy (ICP), small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), macrosomia, and 1st and 5th minutes low APGAR scores (< 7). Results PIHD was significantly higher in LFF (< 4% and < 5th percentile) cases (p = 0.015 and p < 0.001, respectively). However, in population-based quartiles of FF, PIHD did not differ significantly between groups. Composite adverse maternal outcomes were significantly higher in the FF < 4% group (p = 0.042). When analyzes were adjusted for maternal age, BMI, and gestational age at NIPT, significance was maintained at < 4%, < 5th percentile LFF for PIHD, and < 4% LFF for composite adverse maternal outcomes. However, there was no significant relationship between LFF with GDM, ICP and PTB. Additionally, there was no significant association between low APGAR scores, SGA, LGA, LBW, macrosomia, and LFF concerning neonatal outcomes. Conclusion Our study showed that LFF in pregnant women with normal NIPT results may be a predictor of subsequent PIHD.
dc.identifier.doi10.1007/s00404-024-07443-z
dc.identifier.endpage1048
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue2
dc.identifier.pmid38441603
dc.identifier.scopus2-s2.0-85186601863
dc.identifier.scopusqualityQ2
dc.identifier.startpage1037
dc.identifier.urihttps://doi.org/10.1007/s00404-024-07443-z
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2495
dc.identifier.volume310
dc.identifier.wosWOS:001176388900005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectCell-free DNA
dc.subjectFetal fraction
dc.subjectNon-invasive prenatal test
dc.subjectPregnancy-induced hypertensive diseases
dc.subjectPregnancy outcomes
dc.titleAssociation between fetal fraction of cell-free DNA and adverse pregnancy outcomes
dc.typeArticle

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