Ceftazidime-Avibactam Susceptibility of Klebsiella pneumoniae Isolates Obtained from Intensive Care Patients

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dc.contributor.authorSenol, Gunes
dc.contributor.authorDemirel, Mahmut Mete
dc.contributor.authorGunduz, Ayriz Tuba
dc.contributor.authorAkan, Tuba
dc.contributor.authorBicmen, Can
dc.contributor.authorYildirim, Suleyman
dc.date.accessioned2025-03-20T09:41:35Z
dc.date.available2025-03-20T09:41:35Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractObjective: Antibiotic resistance encountered in agents causing intensive care unit (ICU) infections is a considerable problem in treatment. In recent years, multiple antibiotic resistances have been detected, especially in Klebsiella pneumonia iso- lates. Infections caused by these bacteria are difficult to handle and have a high mortality. In this study, the in vitro antimicrobial susceptibility rate of ceftazidime/ avibactam (CAZ-AVI). on K. pneumonia isolates obtained from the samples of ICU patients was investigated. Material and Methods: The study is designed as a cross-sectional cohort. CAZ-AVI susceptibility of K. pneumonia isolates obtained from patients diagnosed with ICU infection was studied by disc diffusion method. Results: Among 37 K. pneumonia isolates isolated from 20 blood, 16 bronchial aspi- rate and one urine samples from ICU patients, 31 (83.7%) were found to be CAZ-AVI susceptible and 6 (16.3%) were resistant. 12 of the isolates are panresistant. It was observed that 3 (25%) of the panresistant strains were resistant to CAZ-AVI and 9 (75%) were susceptible. Conclusion: In our study, it was determined that CAZ-AVI showed a low resistance rate even in K. pneumoniae strains that showed multi-antibiotic resistance. It was thought that it could be an alternative treatment option in ICU infections with antibiotic resistance problems.
dc.identifier.doi10.14744/IGH.2023.85547
dc.identifier.endpage88
dc.identifier.issn1300-4115
dc.identifier.issue2
dc.identifier.startpage84
dc.identifier.trdizinid1250547
dc.identifier.urihttps://doi.org/10.14744/IGH.2023.85547
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1250547
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2004
dc.identifier.volume37
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofİzmir Göğüs Hastanesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250319
dc.subjectEnterobacteriaceae
dc.subjectdrug resistance
dc.subjectCeftazidime/avibactam
dc.subjectKlebsiella pneumoniae.
dc.titleCeftazidime-Avibactam Susceptibility of Klebsiella pneumoniae Isolates Obtained from Intensive Care Patients
dc.typeArticle

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