Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study

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dc.authoridAribas, Zeynep/0000-0003-0469-6917
dc.authoridBakar, Yesim/0000-0002-5603-2891
dc.authorwosidAribas, Zeynep/HZJ-8329-2023
dc.contributor.authorTugral, Alper
dc.contributor.authorAribas, Zeynep
dc.contributor.authorAkyol, Murat
dc.contributor.authorBakar, Yesim
dc.date.accessioned2024-03-09T18:48:43Z
dc.date.available2024-03-09T18:48:43Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackground Chemotherapy is a well-known risk factor for sensorial and motor disturbances. Chemotherapy induced peripheral neuropathy (CIPN) which predominantly affects sensory nerves might cause a diminished fine motor function. This prospective observational study aimed to assess the sensorimotor functions of breast cancer patients before, during, and after chemotherapy.Methods A total of 56 breast cancer patients were evaluated at three different times as follows: T1 (before chemotherapy), T2 (middle chemotherapy), and T3 (completion of chemotherapy). Motor function was assessed with handgrip strength (HGS), peripheral muscle strength (PMS), and the Minnesota Manual Dexterity Test (MMDT). Semmes Weinstein Monofilament Test (SWMT) was performed to assess the sensory function. Fatigue was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Module Cancer Related Fatigue (EORTC-QLQ-FA12), respectively.Results HGS and MMDT were found significant (chi 2: 11.279, p = 0.004 and chi 2: 9.893, p = 0.007, respectively) whereas PMS was not found significant (F (2,110) = 1.914, p = 0.152). Pairwise comparisons with Bonferroni adjustments revealed that HGS was found significant between T1 and T3, while significant results were obtained between T1 and T2 as well as T2 and T3 in MMDT (p = 0.01 and p = 0.042). There were significant results in some reference points of SWMT, though they were not found after pairwise comparisons with Bonferroni adjustment (p > 0.05). Fatigue was found significantly increased from T1 through T3 (Median: 19.44 vs 27.77, z: -2.347, p = 0.019, Wilcoxon test).Conclusion Our study showed that decreased handgrip strength and fine motor function, as well as increased fatigue, are evident during the chemotherapy. SWMT can be an optional assessment in the context of tracking changes in cutaneous sensation during chemotherapy due to its non-invasive, cheap, and easily repeatable features among cancer patients. To preserve functional capacity as well as independence in daily living, precautions and follow up assessments during the systemic therapy process should be integrated as early as possible to prevent future deteriorations in daily life for patients who undergo chemotherapy.en_US
dc.description.sponsorshipThe Authors would like to thank patients who voluntarily participated in this study during their adjuvant and neoadjuvant therapy.en_US
dc.description.sponsorshipThe Authors would like to thank patients who voluntarily participated in this study during their adjuvant and neoadjuvant therapy.en_US
dc.identifier.doi10.1186/s12885-023-11494-x
dc.identifier.issn1471-2407
dc.identifier.issue1en_US
dc.identifier.pmid37838686en_US
dc.identifier.scopus2-s2.0-85174224346en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12885-023-11494-x
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1418
dc.identifier.volume23en_US
dc.identifier.wosWOS:001084776700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Cancer; Chemotherapy; Chemotherapy Induced Peripheral Neuropathy; Fatigue; Handgrip Strength; Peripheral Muscle Strength; Semmes-Weinstein Monofilament Test; Minnesota Manual Dexterity Testen_US
dc.titleAssessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational studyen_US
dc.typeArticleen_US

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