The Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers?

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dc.authoridKOYUNCU OZYURT, OZLEM/0000-0003-1260-0671
dc.authoridAKTAS, Ahmet/0000-0003-3243-6338
dc.contributor.authorEce, Guelfem
dc.contributor.authorAktas, Ahmet
dc.contributor.authorCaner, Ayse
dc.contributor.authorSaglik, Imran
dc.contributor.authorKula Atik, Tugba
dc.contributor.authorBagci, Ozlem Ulusan
dc.contributor.authorBayindir Bilman, Fulya
dc.date.accessioned2025-03-20T09:50:31Z
dc.date.available2025-03-20T09:50:31Z
dc.date.issued2025
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractThe human microbiome, which encompasses microbial communities and their genetic material, significantly influences health and disease, including cancer. The urogenital microbiota, naturally present in the urinary and genital tracts, interact with factors such as age, lifestyle, and health conditions to affect homeostasis and carcinogenesis. Studies suggest that alterations in this microbiota contribute to the development and progression of genitourinary cancers, emphasizing the concept of oncobiome, which refers to microbial genetic contributions to cancer. Similarly, gut microbiota can influence hormone levels and systemic inflammation, impacting cancers such as cervical and prostate cancer. Advanced studies indicate that microbial communities in genitourinary cancers have distinct profiles that may serve as diagnostic biomarkers or therapeutic targets. Dysbiosis of the urinary microbiota correlates with bladder and kidney cancer. Additionally, gut microbiota influence the effectiveness of cancer treatments. However, further research is necessary to clarify causality, the role of microbial metabolites, and hormonal regulation. The aim of this review is to understand that these dynamics present opportunities for innovative cancer diagnostics and therapies, highlighting the need for integration of microbiology, oncology, and genomics to explore the role of microbiota in genitourinary cancers. For this, a comprehensive search of relevant databases was conducted, applying specific inclusion and exclusion criteria to identify studies examining the association between microbiota and urogenital cancers. Research into the mechanisms by which microbiota influence urogenital cancers may pave the way for new diagnostic and therapeutic approaches, ultimately improving patient outcomes.
dc.description.sponsorshipKLIMUD (Society for Clinical Microbiologists of Turkiye); KLIMUD-Microbiome Restoration and Bioinformatics Study Group
dc.description.sponsorshipWe would like to acknowledge the KLIMUD (Society for Clinical Microbiologists of Turkiye) and the KLIMUD-Microbiome Restoration and Bioinformatics Study Group for critical organization and support.
dc.identifier.doi10.3390/microorganisms13020315
dc.identifier.issn2076-2607
dc.identifier.issue2
dc.identifier.pmid40005682
dc.identifier.scopus2-s2.0-85219584194
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/microorganisms13020315
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2234
dc.identifier.volume13
dc.identifier.wosWOS:001430156000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofMicroorganisms
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjecturogenital microbiota
dc.subjectdysbiosis
dc.subjecturogenital cancers
dc.titleThe Urogenital System Microbiota: Is It a New Gamechanger in Urogenital Cancers?
dc.typeReview

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