CD4+CD25+CD127loFOXP3+cell in food allergy: Does it predict anaphylaxis?

Basit Öğe Kaydı
dc.contributor.authorErdem, Semiha Bahceci
dc.contributor.authorGenel, Ferah
dc.contributor.authorNacaroglu, Hikmet Tekin
dc.contributor.authorKaraman, Sait
dc.contributor.authorKarkiner, Canan Sule Unsal
dc.contributor.authorSurucu, Murat
dc.contributor.authorCan, Demet
dc.date.accessioned2024-03-09T18:48:43Z
dc.date.available2024-03-09T18:48:43Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractBackground: Food allergy (FA), hence the incidence of food anaphylaxis, is a public health problem that has increased in recent years. There are still no biomarkers for patients with FA to predict severe allergic reactions such as anaphylaxis. Objective: There is limited information on whether regulatory T (Treg) cell levels are a biomarker that predicts clinical severity in cases presenting with FA, and which patients are at a greater risk for anaphylaxis. Methods: A total of 70 children were included in the study: 25 who had IgE-mediated cow's milk protein allergy (CMPA) and presented with non-anaphylactic symptoms (FA/A-), 16 who had IgE-mediated CMPA and presented with anaphylaxis (FA/A+) (a total of 41 FA cases), and a control group consisting of 29 children without FA. The study was conducted by performing CD4+CD25+CD127(lo)FOXP3+ cell flow cytometric analysis during resting at least 2 weeks after the elimination diet to FA subjects. Results: When the FA group was compared with healthy control subjects, CD4+CD25+CD127(lo)FOXP3+ cell rates were found to be significantly lower in the FA group (p < 0.001). When the FA/A- and FA/A+ groups and the control group were compared in terms of CD4+CD25+CD127(lo)FOXP3+ cell ratios, they were significantly lower in the FA/A- and FA/A+ groups compared to the control group (p < 0.001). Conclusions: Although there was no significant difference between the FA/A+ group and the FA/ A- group in terms of CD4+CD25+CD127(lo)FOXP3+ cells, our study is important, as it is the first pediatric study we know to investigate whether CD4+CD25+CD127(lo)FOXP3+ cells in FA predict anaphylaxis. (c) 2023 Codon Publications. Published by Codon Publications.en_US
dc.identifier.doi10.15586/aei.v51i3.797
dc.identifier.endpage14en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue3en_US
dc.identifier.pmid37169554en_US
dc.identifier.scopus2-s2.0-85158915325en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.15586/aei.v51i3.797
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1435
dc.identifier.volume51en_US
dc.identifier.wosWOS:001036844100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCodon Publicationsen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFoxp3; Treg Cells; Children; Food Allergy; Cow's Milk Protein Allergy; Anaphylaxisen_US
dc.titleCD4+CD25+CD127loFOXP3+cell in food allergy: Does it predict anaphylaxis?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1435.pdf
Boyut:
965.94 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu