The effect of post-reperfusion levosimendan in an experimental intestinal ischemia-reperfusion model

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dc.authoridOlguner, Cimen Gulben/0000-0002-3688-8078
dc.authoridAygun, Hakan/0000-0002-6152-0857
dc.contributor.authorAygun, Hakan
dc.contributor.authorOlguner, Cimen
dc.contributor.authorKoca, Ugur
dc.contributor.authorErgur, Bekir Ugur
dc.contributor.authorSisman, Ali Riza
dc.contributor.authorIsguven, Duyguhan
dc.contributor.authorGirgin, Pelin
dc.date.accessioned2025-03-20T09:50:44Z
dc.date.available2025-03-20T09:50:44Z
dc.date.issued2022
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackgroundLevosimendan has been reported to have a positive effect on ischemia-reperfusion injury. Herein, we aimed to evaluate the effects of levosimendan applied after reperfusion in an experimental intestinal injury-reperfusion (IR) model.MethodsTwenty-one Wistar-albino male rats were separated into three groups: Sham group (n = 7): solely superior mesenteric artery (SMA) was dissected after laparotomy; intestinal ischemia-reperfusion group (IIR, n = 7): SMA was clamped for 60 min and unclamped for 120 min to cause ischemia-reperfusion; IIR + levosimendan group (IIR + L, n = 7): levosimendan was administered in ischemia-reperfusion model. The mean arterial pressures (MAP) were measured in all groups. MAP measurements were performed at the end of stabilization, at the 15th, 30th, and 60th minute of ischemia; at the 15th, 30th, 60th, and 120th minute of reperfusion; and at the end of levosimendan bolus application and when levosimendan infusion concluded. Reperfusion injury was evaluated with tissue malondialdehyde (MDA) and by Chiu score.ResultsMAP at 15 min, 30 min, and 60 min of reperfusion was lower in IIR and IIR + L groups compared with basal inter-group measurements. Decline in MAP at 30 min after reperfusion was statistically significant in IIR and IIR + L groups when compared with the sham group. There was no significant difference between MDA levels in the groups. Chiu score was significantly lower in the sham group when compared to IIR and IIR + L groups and higher in IIR when compared to the IIR + L group.ConclusionLevosimendan leads to a decrease in intestinal damage although it did not affect lipid peroxidation and MAP when administered after reperfusion in an experimental intestinal IR model.
dc.identifier.doi10.1186/s44158-022-00074-3
dc.identifier.issn2731-3786
dc.identifier.issue1
dc.identifier.pmid37386547
dc.identifier.scopus2-s2.0-85149629664
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1186/s44158-022-00074-3
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2280
dc.identifier.volume2
dc.identifier.wosWOS:001319169200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofJournal of Anesthesia Analgesia and Critical Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250319
dc.subjectPhosphodiesterase 3 inhibitors
dc.subjectIschemia
dc.subjectReperfusion
dc.subjectRats
dc.subjectMesenteric vascular occlusion
dc.subjectSimendan
dc.titleThe effect of post-reperfusion levosimendan in an experimental intestinal ischemia-reperfusion model
dc.typeArticle

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