Effects of hyperbaric oxygen therapy on the morphological characteristics and survival of MCF-7 breast cancer cells

Basit Öğe Kaydı
dc.contributor.authorUyanıkgil, Yiğit
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorElbe, Hülya
dc.contributor.authorYücel, Anıl
dc.contributor.authorALLI, Hakan
dc.contributor.authorErgözen, Serkan
dc.contributor.authorÇavuşoğlu, Türker
dc.date.accessioned2024-03-09T20:43:21Z
dc.date.available2024-03-09T20:43:21Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractAim: This study aims to determine the effects of hyperbaric oxygen therapy at different pressure values on cell morphology and cell survival in the MCF-7 breast cancer cell line. Materials and Methods: The experimental groups were formed by applying 100% oxygen to MCF-7 breast cancer cells at 1.5, 2, and 2.5 atmospheres for 2 hours. The control group did not receive treatment. At the end of the experiment, cell survival was investigated by CCK-8 analysis, cell shapes were determined by cresyl violet staining, and cell surface morphologies were determined by scanning electron microscope. Results: Cell viability was significantly reduced at atmospheric pressure of 1.5, 2, and 2.5 compared to the control group (p < 0.005). As pressure increased, the surface area of the cell decreased, nuclear condensation increased, and the cell borders became irregular. Cell membrane bleb and cell membrane porosity increased at 2 and 2.5 atmospheres. Conclusion: Hyperbaric oxygen therapy severely reduces the viability of MCF-7 breast cancer cells under increased pressure. It can induce apoptosis and change the shape and surface morphology of MCF-7 breast cancer cells. Although further studies are needed, our study supports the potential use of hyperbaric oxygen therapy in the treatment of breast cancer.en_US
dc.identifier.endpage17en_US
dc.identifier.issn1016-9113
dc.identifier.issn2147-6500
dc.identifier.issue1en_US
dc.identifier.startpage12en_US
dc.identifier.trdizinid1158988en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1158988
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1764
dc.identifier.volume62en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEge Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of hyperbaric oxygen therapy on the morphological characteristics and survival of MCF-7 breast cancer cellsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1764.pdf
Boyut:
806.53 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu