Zinc (Zn) and adipose-derived mesenchymal stem cells (AD-MSCs) on MPTP-induced Parkinson's disease model: A comparative evaluation of behavioral and immunohistochemical results

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dc.authoridoylumlu, ece/0000-0003-4234-9086
dc.authoridOzkan, Ayse/0000-0001-8186-4852
dc.authorwosidoylumlu, ece/IAR-2432-2023
dc.authorwosidOzkan, Ayse/AHE-5409-2022
dc.contributor.authorYildirim, Sendegul
dc.contributor.authorOylumlu, Ece
dc.contributor.authorOzkan, Ayse
dc.contributor.authorSinen, Osman
dc.contributor.authorBulbul, Mehmet
dc.contributor.authorGoksu, Ethem Taner
dc.contributor.authorErtosun, Mustafa Gokhan
dc.date.accessioned2024-03-09T18:48:28Z
dc.date.available2024-03-09T18:48:28Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractParkinson's disease (PD) is characterized by the loss of dopaminergic neurons and sustained neuroinflammation due to microglial activation. Adipose tissue-derived mesenchymal stem cells (AD-MSCs) secrete neuroprotective factors to prevent neuronal damage. Furthermore, Zn regulates stem cell proliferation and differentiation and has immunomodulatory functions.Our in vivo study aimed to investigate whether Zn affects the activities of AD-MSCs in the MPTP-induced mouse model.Male C57BL/6 mice were randomly divided into six groups (n = 6): Control, Zn, PD, PD+Zn, PD+ (AD-MSC), PD+ (AD-MSC)+Zn. MPTP toxin (20 mg/kg) was dissolved in saline and intraperitoneally injected into exper-imental groups for two days with 12 h intervals. On the 3rd day, AD-MSCs were given to the right lateral ventricle of the PD+ (AD-MSC) and PD+ (AD-MSC)+Zn groups by stereotaxic surgery. Then, ZnSO4H2O was administered intraperitoneally for 4 days at 2 mg/kg. Seven days post MPTP injection, the motor activities of the mouse were evaluated. Then immunohistochemical analyzes were performed in SNpc.Our results showed that motor activity was lower in Group PD. AD-MSC and Zn administration have improved this impairment. MPTP caused a decrease in TH and BDNF expressions in dopaminergic neurons in Group PD. However, TH and BDNF expressions were more intense in the other groups. MCP-1, TGF-& beta;, and IL-10 expressions increased in administered groups compared to the Group PD.en_US
dc.description.sponsorshipAkdeniz University Scientific Research Projects [TSA-2022-5710]en_US
dc.description.sponsorshipAcknowledgments This study was supported by Akdeniz University Scientific Research Projects with project number TSA-2022-5710. Special thanks to Selin Candir for language editing.en_US
dc.identifier.doi10.1016/j.neuro.2023.05.002
dc.identifier.endpage11en_US
dc.identifier.issn0161-813X
dc.identifier.issn1872-9711
dc.identifier.pmid37146888en_US
dc.identifier.scopus2-s2.0-85158851985en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuro.2023.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1316
dc.identifier.volume97en_US
dc.identifier.wosWOS:001033048600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofNeurotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson's Disease; Ad -Msc; Zn; Dopaminergic Neuron; Anti-Inflammatory Responseen_US
dc.titleZinc (Zn) and adipose-derived mesenchymal stem cells (AD-MSCs) on MPTP-induced Parkinson's disease model: A comparative evaluation of behavioral and immunohistochemical resultsen_US
dc.typeArticleen_US

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