The effect of progesterone supplementation in women with threatened miscarriage on fetal fraction in non-invasive prenatal testing: A matched case-control study

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dc.authoridKOC, Altug/0000-0002-8366-6806
dc.authoridileri, alper/0000-0002-4713-5805
dc.authoridyıldırım karaca, suna/0000-0001-6633-0342
dc.authoridGölbaşı, Hakan/0000-0001-8682-5537
dc.authoridÖzer, Mehmet/0000-0003-0683-0710
dc.authoridOZEREN, MEHMET/0000-0002-4552-9042
dc.authorwosidKOC, Altug/AAH-3159-2020
dc.authorwosidKARACA, İBRAHİM/K-6772-2019
dc.authorwosidileri, alper/IZP-6427-2023
dc.authorwosidyıldırım karaca, suna/AAR-3466-2020
dc.authorwosidGölbaşı, Hakan/AAS-6783-2021
dc.authorwosidÖzer, Mehmet/JEF-6127-2023
dc.contributor.authorIleri, Alper
dc.contributor.authorKaraca, Suna Yildirim
dc.contributor.authorIleri, Hande
dc.contributor.authorKaraca, Ibrahim
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorOzer, Mehmet
dc.contributor.authorBudak, Adnan
dc.date.accessioned2024-03-09T18:48:21Z
dc.date.available2024-03-09T18:48:21Z
dc.date.issued2023
dc.departmentİzmir Bakırçay Üniversitesien_US
dc.description.abstractAim: To evaluate the effect of progesterone use on fetal fraction (FF) in non-invasive prenatal testing (NIPT) due to the threat of first trimester miscarriage.Methods: This case control study included the pregnant who were referred to our clinic for non-invasive prenatal testing. The patients were categorized into three groups: Pregnant women with vaginal bleeding and using progesterone, pregnant women with vaginal bleeding and not using progesterone, and pregnant women without bleeding. The groups were formed by matching gestational week. Women with multiple pregnancy, BMI (body mass index) >= 25, abnormal fetal karyotype, and chronic disease were excluded from the study. Maternal characteristics, FF of the NIPT were recruited from the computer based medical records.Results: A total of 10,275 NIPT tests were performed during the study period. 3% of the patients (n = 308) were found at risk of miscarriage. 100 patients with a vaginal bleeding and 50 control patients were matched. The median value of the fetal fraction ratio was found to be 6.55 in pregnant women without vaginal bleeding, 7.05 in pregnant women who had vaginal bleeding and using progesterone, and 7.3 in pregnant women who had vaginal bleeding and did not use progesterone. Although the fetal fraction ratio was found to be higher in pregnant women with vaginal bleeding and lower in progesterone users, this situation could not reach the level of statistical significance (p = 0.351).Conclusions: The fetal fraction rate in maternal blood is not affected in pregnant women who use progesterone due to vaginal bleeding in early gestational weeks.en_US
dc.identifier.doi10.1016/j.jogoh.2023.102662
dc.identifier.issn2468-7847
dc.identifier.issn1773-0430
dc.identifier.issue8en_US
dc.identifier.pmid37659577en_US
dc.identifier.scopus2-s2.0-85169508882en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2023.102662
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1308
dc.identifier.volume52en_US
dc.identifier.wosWOS:001074540300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corp Offen_US
dc.relation.ispartofJournal of Gynecology Obstetrics and Human Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNon-Invasive Prenatal Testing; Prenatal Diagnosis; Progesteroneen_US
dc.titleThe effect of progesterone supplementation in women with threatened miscarriage on fetal fraction in non-invasive prenatal testing: A matched case-control studyen_US
dc.typeArticleen_US

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