Clinical and Treatment Evaluation of Anaphylaxis in Children Aged 0-2 Years: Multicenter Study

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dc.contributor.authorSelmanoglu, Ahmet
dc.contributor.authorHaci, Idil Akay
dc.contributor.authorKoc, Fatih Sultan Mehmet
dc.contributor.authorYildiz, Yuksel Kavas
dc.contributor.authorYilmaz, Ebru Arik
dc.contributor.authorAzkur, Dilek
dc.contributor.authorErdem, Semiha Bahceci
dc.date.accessioned2025-03-20T09:51:04Z
dc.date.available2025-03-20T09:51:04Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackgroundDiagnosing anaphylaxis in children within the first 2 years of life can be difficult due to the often confusing and nonspecific signs and symptoms.ObjectiveThis study focuses on the phenotype of anaphylaxis in children within the first 2 years of life and aims to increase awareness of anaphylaxis in this age group.MethodsThe study included children between 0 and 2 years who were diagnosed as having anaphylaxis by pediatric allergists in 11 tertiary hospitals.ResultsA total of 402 anaphylaxis episodes experienced by 360 patients (68.7% males) were included in the study. Food was the most common causative agent (n = 374, 93%), with the most common foods being cow's milk (n = 179, 44.6%). Drugs were the second most common trigger (n = 15, 3.7%). The most common clinical findings were cutaneous (95%) and respiratory (72%); nonspecific symptoms such as weakness (n = 63, 15.6%) and hoarseness (n = 14, 3.4%) were also reported. There was a biphasic course in 3 infants (0.8%). Only 3 of the 41 parents who had an adrenaline autoinjector used it during anaphylaxis.ConclusionInfants experience anaphylaxis most often when they are at home with their mothers, and the most common triggers are foods, particularly cow's milk and egg. Greater awareness of anaphylaxis symptoms and autoinjector use among mothers can facilitate management.ImpactInfant anaphylaxis cases may present with different symptoms compared to classic presentations, potentially leading to diagnostic oversight.The study elucidates the clinical course of anaphylaxis in children under 2 years of age.It details the treatment strategies employed in managing these cases.Anaphylaxis triggers were identified over several years.Cases from 11 regions of Turkey were included, representing a population reflective of national data.The study highlights the distinctiveness of anaphylaxis cases in children within the first 2 years of life.
dc.identifier.doi10.1038/s41390-024-03720-4
dc.identifier.issn0031-3998
dc.identifier.issn1530-0447
dc.identifier.pmid39558120
dc.identifier.scopus2-s2.0-85209353433
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41390-024-03720-4
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2396
dc.identifier.wosWOS:001357707000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofPediatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectPosition Paper
dc.subjectEuropean Academy
dc.subjectManagement
dc.subjectDiagnosis
dc.subjectAllergy
dc.subjectEpidemiology
dc.subjectPredictors
dc.subjectChallenges
dc.subjectInfants
dc.subjectUpdate
dc.titleClinical and Treatment Evaluation of Anaphylaxis in Children Aged 0-2 Years: Multicenter Study
dc.typeArticle

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