View of Perceived Symptoms Associated with Chemotherapyinduced Peripheral Neuropathy in Patients with Breast Cancer: A Cross-sectional Study

Basit Öğe Kaydı
dc.contributor.authorTuğral, Alper
dc.contributor.authorAkyol, Murat
dc.date.accessioned2025-03-20T09:41:22Z
dc.date.available2025-03-20T09:41:22Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractObjective: This cross-sectional study aimed to assess the perceived chemotherapy-induced peripheral neuropathy (CIPN) symptoms in patients with breast cancer who received taxane-based chemotherapy. Methods: A total of 74 patients with breast cancer who underwent taxane-based chemotherapy were screened and invited to participate in this study. Perceived symptoms of CIPN were assessed via the European Organization for Research and Treatment of Cancer-Chemotherapy Induced Peripheral Neuropathy (EORTC-CIPN20) questionnaire after the completion of systemic treatment within a month and a half. Sensory, motor, and autonomic subscale scores were calculated and analyzed for each patient. Results: This study included 52 patients with breast cancer. The mean total exposure dose was 2093.92±1266.22 mg. The rates of adjuvant and neoadjuvant chemotherapy were similar (n=25 vs. n=27). Most patients underwent breast-conserving surgery (65.4%). The types of chemotherapy regimen were combined anthracycline and paclitaxel (n=28), docetaxel (n=14), and combined anthracycline, pertuzumab, trastuzumab, and docetaxel (n=10). Patients who underwent modified radical mastectomy had significantly higher scores in the perceived symptoms of CIPN motor function subscale of EORTCCIPN20 (z=-2.838, p=0.005). The autonomic subscale of EORTC-CIPN20 was significantly correlated with age (r=-0.373, p=0.006) and with the total exposure dose of chemotherapy (r=0.295, p=0.034). Conclusion: The type of surgery, specifically MRM, which has been emphasized as a contributing factor to CIPN, should be taken into consideration for further potential deterioration. By this means, it is reasonable to state that not only ongoing monitoring of the CIPN is of utmost importance, but also potential contributors to the management of the CIPN are of great importance.
dc.identifier.doi10.4274/forbes.galenos.2024.17363
dc.identifier.endpage115
dc.identifier.issn2717-9443
dc.identifier.issn2757-5241
dc.identifier.issue2
dc.identifier.startpage108
dc.identifier.trdizinid1277729
dc.identifier.urihttps://doi.org/10.4274/forbes.galenos.2024.17363
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1277729
dc.identifier.urihttps://hdl.handle.net/20.500.14034/1925
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofForbes tıp dergisi (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250319
dc.subjectBreast cancer
dc.subjectchemotherapy
dc.subjectperipheral neuropathy
dc.subjecttaxane
dc.titleView of Perceived Symptoms Associated with Chemotherapyinduced Peripheral Neuropathy in Patients with Breast Cancer: A Cross-sectional Study
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu