THE ETIOLOGICAL RELATIONSHIP OF OBSTRUCTIVE SLEEP APNEA-OBESITY AND CAROTID ATHEROSCLEROSIS
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for the presence of cerebral small-vessel disease, stroke and burden of cerebral atherosclerosis and it is frequently associated with comorbidities such as obesity, metabolic disorders, hypertension, coronary artery disease, circulatory insufficiency, and carotid atherosclerosis, all of which contribute to adverse effects on the cerebrovascular system. This study aimed to analyze the relationship between carotid atherosclerosis (CA) and obesity, vascular risk factors in patients with OSAS. METHODS: In this retrospective study, we reviewed patients admitted to neurology and chest diseases outpatient clinic with sleep apnea syndrome and hospitalized during nightime for Polysomnography between September 2020-June 2023. Patients with moderate or severe OSAS who underwent bilateral carotid artery Doppler USG for any reason within six months were included in the study group. The control group included the patients meeting criteria who admitted to neurology outpatient clinic. Body Mass Index (BMI) of all patients was calculated as weight (kg) /height (m2). Patients with acute or chronic upper airway or lung infection, severe obstructive or restrictive lung diseases, acute-subacute stroke and myocardial infarction, heart or renal failure, patients with a history of major surgery within six months were also excluded. RESULTS: According to the inclusion and exclusion criteria, 47 patients with moderate or severe OSAS and 40 patients without OSAS were recruited. Male sex and patients with obesity (BMI>30 kg/m2) were more prevalent in the study group and the difference was statistically significant (P<0,05). However, the incidence of CA was similar between all groups, there was no significant difference. DISCUSSION AND CONCLUSION: Although obesity was more common in the OSAS group, the number of patients with CA or stenosis was similar in both groups. The findings suggest that well-known vascular risk factors and comorbidities may have a primary effect on atherogenesis, rather than a direct effect of OSAS.
Açıklama
Anahtar Kelimeler
Obesity, comorbidities, stroke, OSAS, carotid atherosclerosis
