Diagnostic Efficacy of Cell Block and Liquid-Based Cytology for Endoscopic Ultrasound-Guided Fine Needle Aspiration in Pancreatic Tumors

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dc.contributor.authorSenkaya, Ali
dc.contributor.authorCelik, Ferit
dc.contributor.authorTekin, Fatih
dc.contributor.authorTuran, Ilker
dc.contributor.authorNart, Deniz
dc.contributor.authorOruc, Nevin
dc.contributor.authorAydin, Ahmet
dc.date.accessioned2025-03-20T09:50:27Z
dc.date.available2025-03-20T09:50:27Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBackground/Aims: This study aimed to evaluate the diagnostic efficacy of cell block (CB) and liquid-based cytology (LBC) for endo-scopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic tumors. Materials and Methods: The study included patients who underwent EUS-FNA for pancreatic tumors between January 2015 and February 2021 and whose cytology samples were both processed for LBC and CB. Results: Data of 390 patients (220 men, mean age: 64.2 +/- 11.4 years) were retrospectively analyzed. Of the detected lesions (size: 17-120 mm; mean: 39.9 +/- 13.9 mm), 220 (56.4%) were located in the head and uncinate process of the pancreas. Lesions in 339 (86.9%) patients were diagnosed as malignant using CB and/or LBC and suspicious for malignancy in 44 (11.3%) patients. In 7 patients with non-diagnostic (6 cases) or negative for malignancy (1 case) EUS-FNA results using both methods, the diagnosis of malignancy was established via ultrasound-guided percutaneous biopsy. Malignancy was detected in 324 (92.4%), 313 (87.9%), and 298 (87.9%) patients using CB, LBC, and both CB and LBC, respectively. Final diagnosis was obtained in 339 (98%) patients by using CB and/or LBC. The combined use of the both methods exhibited significantly superior diagnostic accuracy compared with CB and LBC alone (P < .001). Conclusion: Liquid-based cytology and CB exhibit high diagnostic accuracy for the detection of pancreatic tumors in patients undergoing EUS-FNA. The combined use of both methods showed a significantly higher diagnostic accuracy than LBC and CB alone.
dc.identifier.doi10.5152/tjg.2024.23609
dc.identifier.issn2148-5607
dc.identifier.issue8
dc.identifier.pmid39155569
dc.identifier.scopus2-s2.0-85201623642
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.5152/tjg.2024.23609
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2196
dc.identifier.volume35
dc.identifier.wosWOS:001318111800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectEndoscopic ultrasound-guided fine needle aspiration
dc.subjectpancreatic neoplasms
dc.subjectcytopathology
dc.subjectdiagnosis
dc.titleDiagnostic Efficacy of Cell Block and Liquid-Based Cytology for Endoscopic Ultrasound-Guided Fine Needle Aspiration in Pancreatic Tumors
dc.typeArticle

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