Advanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review

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dc.authoridRodriguez-Emmenegger, Cesar/0000-0003-0745-0840
dc.contributor.authorKasapgil, Esra
dc.contributor.authorGaray-Sarmiento, Manuela
dc.contributor.authorRodriguez-Emmenegger, Cesar
dc.date.accessioned2025-03-20T09:51:24Z
dc.date.available2025-03-20T09:51:24Z
dc.date.issued2024
dc.departmentİzmir Bakırçay Üniversitesi
dc.description.abstractBiomaterial-associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in-depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial-eluting biomaterials, contact-killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology.
dc.description.sponsorshipPERIS 2022- 2027/Proves de validacio; SIC-BIO group of the Government of Catalonia [SGR 01545]; German Federal Ministry of Education and Research (BMBF); European Innovation Council (EIC) under the European Union' [101115545]; Scientific and Technological Research Council of Turkiye (TUBITAK) [2219]; Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR); Government of Catalonia through the Beatriu de Pinos Programme; [SLT033/23/000037]; [031B1153A]; [031B1154B]; [BP 00085]
dc.description.sponsorshipThis work was supported by PERIS 2022- 2027/Proves de validacio (Grant Number SLT033/23/000037) and the SIC-BIO group (2021 SGR 01545) of the Government of Catalonia, the German Federal Ministry of Education and Research (BMBF) with the projects AntiBacCat and Heart2.0 within the Bio4MatPro- Competence Center for Biological Transformation of Materials Science and Production Engineering program (Grant Numbers 031B1153A and 031B1154B), and European Innovation Council (EIC) under the European Union's Horizon Europe programme, IV- Lab, project number: 101115545. E.K. supported from The Scientific and Technological Research Council of Turkiye (TUBITAK, Program Number 2219) and the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) and the Government of Catalonia through the Beatriu de Pinos Programme (2023 BP 00085).
dc.identifier.doi10.1002/wnan.2018
dc.identifier.issn1939-5116
dc.identifier.issn1939-0041
dc.identifier.issue6
dc.identifier.pmid39654369
dc.identifier.scopus2-s2.0-85211480276
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1002/wnan.2018
dc.identifier.urihttps://hdl.handle.net/20.500.14034/2533
dc.identifier.volume16
dc.identifier.wosWOS:001372613400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofWiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250319
dc.subjectantifouling coatings
dc.subjectantimicrobial-eluting coatings
dc.subjectbiomaterial-associated infections
dc.subjectcontact killing coatings
dc.subjectmultifunctional antimicrobial coatings
dc.titleAdvanced Antibacterial Strategies for Combatting Biomaterial-Associated Infections: A Comprehensive Review
dc.typeReview

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